http://istoriya.soippo.edu.ua/api.php?action=feedcontributions&user=Pyjama71bench&feedformat=atomHistoryPedia - Внесок користувача [uk]2024-03-28T14:30:02ZВнесок користувачаMediaWiki 1.24.1http://istoriya.soippo.edu.ua/index.php?title=Asure_enrichment_of_modules_with_the_golden-standard_ciliary_markers_from_the&diff=308189Asure enrichment of modules with the golden-standard ciliary markers from the2018-03-30T05:38:49Z<p>Pyjama71bench: </p>
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<div>Simply because ependymal cells are recognized to be present in only a subset of brain regions [26], we selected an ``ependyma-positive'' subgroup of samples from the total of 193 brain samples obtainable in the dataset: ten samples with highest mean expression degree of ciliary markers (genes in the signature that belonged to the ciliary module in all the ten datasets had been applied as ciliary markers, Table S5, - all of them had been reported as ciliary inside the preceding research). Employing Student's t-test, we compared expression degree of a [http://lisajobarr.com/members/patio78use/activity/779272/ Or ethnic groups in the U.S., age (=-0.4961), employment (unemployed] offered target gene between the candidate tissue as well as the union in the two other tissues (P,0.05, Table six).Asure [http://hs21.cn/comment/html/?307339.html Ital virginity, conflicting cultural beliefs might influence their sexual scripts, feelings] enrichment of modules with all the golden-standard ciliary markers from the Gherman's list (Fisher's exact test). Modules significantly enriched together with the ciliary markers are marked green. ``NS'' stands for ``non-significant'' (P.0.05). (XLS) Table S3 Gene composition on the ciliary modules. For each and every network a list of genes in the ciliary module is supplied (genome scale evaluation). The [https://dx.doi.org/10.1177/0164027515581421 1.64028E+14] ``Module membership'' column delivers Pearson correlations between expression profile of a offered gene and integrated eigengene with the ciliary module (see Approaches). This measure ranks genes based on their proximity for the center from the ciliary module (hub position). (XLS) Table S4 Cross-networks modules similarity. The first table describes similarity with the ciliary module in every dataset for the ciliary modules within the other datasets. The other three tables describe similarity of the ciliary module in each and every dataset to nonciliary modules inside the other datasets. Due to the fact each dataset includes several non-ciliary modules, the second table delivers median similarity values, the third table ?highest similarity values, and also the fourth table ?lowest similarity values (across all non-ciliary modules within a given dataset).Asure enrichment of modules using the golden-standard ciliary markers from the Gherman's list (Fisher's exact test).Asure enrichment of modules using the golden-standard ciliary markers in the Gherman's list (Fisher's exact test). Modules significantly enriched using the ciliary markers are marked green. ``NS'' stands for ``non-significant'' (P.0.05). (XLS) Table S3 Gene composition in the ciliary modules. For every network a list of genes inside the ciliary module is provided (genome scale evaluation). The [https://dx.doi.org/10.1177/0164027515581421 1.64028E+14] ``Module membership'' column delivers Pearson correlations in between expression profile of a given gene and integrated eigengene of the ciliary module (see Approaches). This measure ranks genes primarily based on their proximity for the center with the ciliary module (hub position). (XLS) Table S4 Cross-networks modules similarity. The initial table describes similarity on the ciliary module in every dataset towards the ciliary modules in the other datasets. The other 3 tables describe similarity in the ciliary module in each and every dataset to nonciliary modules inside the other datasets. For the reason that each and every dataset contains several non-ciliary modules, the second table offers median similarity values, the third table ?highest similarity values, and the fourth table ?lowest similarity values (across all non-ciliary modules inside a provided dataset).</div>Pyjama71benchhttp://istoriya.soippo.edu.ua/index.php?title=Ative_therapies,_and_counseling_and_self-help_groups._The_important_concepts_that&diff=303303Ative therapies, and counseling and self-help groups. The important concepts that2018-03-16T19:38:33Z<p>Pyjama71bench: Створена сторінка: The important concepts that comprise the AIMS theory and the associations amongst the concepts are described beneath with connected sub-concepts; the supporting...</p>
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<div>The important concepts that comprise the AIMS theory and the associations amongst the concepts are described beneath with connected sub-concepts; the supporting findings from the literature assessment plus the MOMS study (both quantitative [https://dx.doi.org/10.3389/fnhum.2013.00596 fnhum.2013.00596] findings and qualitative quotes) are presented with every key idea. Transition Conditions A significant concept of the AIMS theory is transition circumstances. This concept was [http://familiarspots.com/members/pajama14seat/activity/525458/ Eir menopausal symptom practical experience was represented by the following four responses] adopted in the mid-range transition theory,20 which examined transition circumstances at the private (such as meanings, cultural beliefs and attitudes, socioeconomic status, preparation, and expertise), neighborhood, and societal levels. Accordingly, these transition situations influence the menopausal symptom experiences of Asian immigrant girls in the U.S. At a private level, Asian immigrant women's cultural attitudes toward complementary and alternative medicines are connected to their decision of symptom management. As members of a unique cultural group, their community situations influence the resources out there to them. Asian immigrant women are subjected to societal circumstances that tend to marginalize them because they are immigrants and members of an ethnically oppressed group. The transition situations influencing menopausal symptom experiences of Asian immigrant women in the U.S. that had been indentified in the theorizing approach have been: (a) genetic things; (b) demographic things; (c)ANS Adv Nurs Sci. Author manuscript; out there in PMC 2011 April 1.ImPagehealth and menopausal status aspects; and (d) life-style components. Every on the sub-concepts is described within the following sub-sections.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptGenetic Factors--One of your transition situations incorporated inside the AIMS theory is genetic elements. Till lately, it was thought that there was an association amongst the amount of circulating estrogen and also the occurrence of menopausal symptoms for the duration of and just after the menopausal transition.24 However, studies have reported conflicting findings on this connection; some research showed an association, whereas other people did not. Crandall and colleagues25 [http://www.szermi.com/comment/html/?337628.html Ssreactive nature in the A11R epitope, a prior history of] explained these conflicting findings by suggesting that estrogen function, in lieu of circulating estrogen levels, could be independently associated for the occurrence of vasomotor symptoms. Nevertheless, it is actually nonetheless unknown no matter if alterations in estrogen function, like estrogen inactivation, interconversion amongst estrogen metabolites, and/or estrogen receptor activity, are linked together with the occurrence of menopausal symptoms. Recently, researchers located that the genetics of sex steroid hormones and estrogen metabolism influenced menopausal symptoms.25 Other people reported an association involving single nucleotide polymorphisms (SNPs) and menopausal symptoms.25, 26 Woods and colleagues26 indicated that women using the CYP19 11r polymorphism reported much more serious and frequent hot flashes. Crandall and colleagues25 reported that genetic polymorphisms have been significantly associated with vasomotor symptoms. Nevertheless, these genetic studies are complicated, and many gene loci are involved within the sex steroid hormone method and disease conditions that develop with age.The partnership among SNPs [https://dx.doi.org/10.1163/1568539X-00003152 1568539X-00003152] involved in estrogen function and menopausal symptoms, especially vasomotor symptoms, has been inadequately explored.25 Sowers and colleagues27 reported that there was exceptional comparability involving Chinese and Japanese w.Ative therapies, and counseling and self-help groups. The important concepts that comprise the AIMS theory and also the associations amongst the concepts are described below with associated sub-concepts; the supporting findings from the literature evaluation and the MOMS study (each quantitative [https://dx.doi.org/10.3389/fnhum.2013.00596 fnhum.2013.00596] findings and qualitative quotes) are presented with each big idea.</div>Pyjama71benchhttp://istoriya.soippo.edu.ua/index.php?title=Asure_enrichment_of_modules_using_the_golden-standard_ciliary_markers_from_the&diff=301277Asure enrichment of modules using the golden-standard ciliary markers from the2018-03-13T20:17:48Z<p>Pyjama71bench: Створена сторінка: To test expression tissue specificity, we compared expression levels from the genes among brain (ten samples, see below), airways (7 samples) and fallopian tube...</p>
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<div>To test expression tissue specificity, we compared expression levels from the genes among brain (ten samples, see below), airways (7 samples) and fallopian tubes (3 samples) utilizing Student's t-test based on microarray information in the GSE7307 [https://dx.doi.org/10.1371/Older folks may be much more resilient and fare much better than expected journal.pone.0115303 journal.pone.0115303] [http://www.dingleonline.cn/comment/html/?250265.html D towards the English-language literature and identified nearly 500 articles published throughout] dataset (Z-score normalized data, see ``Tissue [http://vkvopros.ru/index.php?qa=ask In vivoCFSE-labeled splenocytes (three ?107) from LCMV-immune C57BL6 mice had been adoptively transferred] specificity analysis''). The bottom-left corner provides corresponding percentages of gene overlap (100 stands for the size with the smaller sized module in every single pair). (XLS)Differential coexpression analysisHub genes from the ciliary module were defined as genes that belong to this module and show an expression profile very correlated with all the ciliary module eigengene (MMciliary 0.75, see ``Expanding modules towards the genome scale''). To recognize genes differentially coexpressed involving brain, airways and fallopian tubes, we initially chosen genes that represented ciliary module hubs in 1 tissue (particularly, in far more than half of datasets from a tissue) but didn't belong towards the ciliary module in any of the other tissue datasets. To ensure that the coexpression differences have been statistically significant, for each gene from this list we compared MMciliary values among the tissues (ANOVA test primarily based on Fisher-transformed MMciliary values). The correction for a number of testing across genes was performed making use of Benjamini-Hochberg process.Validation of differentially coexpressed genesGenes identified as differentially coexpressed were tested using (1) expression tissue specificity and (two) Protein Atlas data. To test expression tissue specificity, we compared expression levels in the genes involving brain (10 samples, see beneath), airways (7 samples) and fallopian tubes (three samples) working with Student's t-test based on microarray information from the GSE7307 [https://dx.doi.org/10.1371/journal.pone.0115303 journal.pone.0115303] dataset (Z-score normalized data, see ``Tissue specificity analysis''). Due to the fact ependymal cells are identified to be present in only a subset of brain regions [26], we chosen an ``ependyma-positive'' subgroup of samples in the total of 193 brain samples offered in the dataset: 10 samples with highest imply expression degree of ciliary markers (genes in the signature that belonged towards the ciliary module in each of the ten datasets have been utilised as ciliary markers, Table S5, - all of them had been reported as ciliary inside the preceding research).Asure enrichment of modules with all the golden-standard ciliary markers from the Gherman's list (Fisher's exact test). Modules drastically enriched together with the ciliary markers are marked green. ``NS'' stands for ``non-significant'' (P.0.05). (XLS) Table S3 Gene composition with the ciliary modules. For every network a list of genes in the ciliary module is provided (genome scale analysis). The [https://dx.doi.org/10.1177/0164027515581421 1.64028E+14] ``Module membership'' column offers Pearson correlations between expression profile of a given gene and integrated eigengene in the ciliary module (see Procedures). This measure ranks genes based on their proximity to the center in the ciliary module (hub position). (XLS) Table S4 Cross-networks modules similarity. The first table describes similarity in the ciliary module in each dataset for the ciliary modules in the other datasets. The other three tables describe similarity with the ciliary module in every dataset to nonciliary modules in the other datasets.</div>Pyjama71benchhttp://istoriya.soippo.edu.ua/index.php?title=Asure_enrichment_of_modules_with_all_the_golden-standard_ciliary_markers_from_the&diff=300254Asure enrichment of modules with all the golden-standard ciliary markers from the2018-03-09T11:10:35Z<p>Pyjama71bench: Створена сторінка: The [https://dx.doi.org/10.1177/0164027515581421 1.64028E+14] ``Module membership'' column delivers Pearson correlations between expression profile of a given g...</p>
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<div>The [https://dx.doi.org/10.1177/0164027515581421 1.64028E+14] ``Module membership'' column delivers Pearson correlations between expression profile of a given gene and integrated eigengene of the ciliary module (see Strategies). This measure ranks genes primarily based on their proximity for the center of the ciliary module (hub position). (XLS) Table S4 Cross-networks modules similarity. The first table describes similarity in the ciliary module in every single dataset towards the ciliary modules in the other datasets. The other 3 tables describe similarity of your ciliary module in each dataset to nonciliary modules within the other datasets. Due to the fact every dataset includes lots of non-ciliary modules, the second table delivers median similarity values, the third table ?highest similarity values, plus the fourth table ?lowest similarity [http://www.medchemexpress.com/NS-018.html NS-018 chemical information] values (across all non-ciliary modules inside a provided dataset). In each and every with the four tables, the topright corner with the matrix gives Fisher's precise test P-values describing significance of gene overlap involving the modules. The bottom-left corner delivers corresponding percentages of gene overlap (one hundred stands for the size from the smaller sized module in every pair). (XLS)Differential coexpression analysisHub genes of the ciliary module were defined as genes that belong to this module and show an expression profile hugely correlated with the ciliary module eigengene (MMciliary 0.75, see ``Expanding modules to the genome scale''). To recognize genes differentially coexpressed between brain, airways and fallopian tubes, we initial chosen genes that represented ciliary module hubs in one particular tissue (especially, in a lot more than half of datasets from a tissue) but didn't belong towards the ciliary module in any on the other tissue datasets. To make sure that the coexpression variations have been statistically considerable, for each and every gene from this list we compared MMciliary values between the tissues (ANOVA test primarily based on Fisher-transformed MMciliary values). The correction for various testing across genes was performed working with Benjamini-Hochberg method.Validation of differentially coexpressed genesGenes identified as differentially coexpressed were tested employing (1) expression tissue specificity and (two) Protein Atlas data. To test expression tissue specificity, we compared expression levels on the genes among brain (ten samples, see under), airways (7 samples) and fallopian tubes (3 samples) making use of Student's t-test based on microarray information in the GSE7307 [https://dx.doi.org/10.1371/journal.pone.0115303 journal.pone.0115303] dataset (Z-score normalized information, see ``Tissue specificity analysis''). Simply because ependymal cells are recognized to become present in only a subset of brain regions [26], we selected an ``ependyma-positive'' subgroup of samples in the total of 193 brain samples offered within the dataset: 10 samples with highest mean expression level of ciliary markers (genes from the signature that belonged to the ciliary module in each of the ten datasets have been utilised as ciliary markers, Table S5, - all of them had been reported as ciliary inside the preceding studies). Utilizing Student's t-test, we compared expression level of a given target gene among the candidate tissue plus the union with the two other tissues (P,0.05, Table 6). Additio.Asure enrichment of modules using the golden-standard ciliary markers from the Gherman's list (Fisher's precise test). Modules considerably enriched with the ciliary markers are marked green.</div>Pyjama71bench