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Differences in predictor variables frequencies between patients [http://www.selleckchem.com/products/BEZ235.html Selleckchem Dactolisib] with and without a critical care intervention are presented in Table 5. Binary recursive partitioning derived a rule with the following three predictor variables for requiring a critical care intervention: Abnormal mental status (GCS?[http://www.selleckchem.com/products/Vorinostat-saha.html see more] injury; one patient requiring endotracheal intubation for neurological deterioration during ED evaluation and another patient underwent craniotomy for an epidural haematoma. One patient received FFP transfusions for a pre-existing coagulopathy and another patient underwent endotracheal intubation on hospital day three for delirium tremens. All patients survived to hospital discharge. The primary objective of this study was to derive a clinical decision rule to identify a subset of low risk patients with tICH who do not need to be admitted to the ICU. Using binary recursive partitioning, we were able to develop a decision rule with excellent test characteristics. The results are promising for a number of reasons. First, the rule is highly sensitive in detecting a large number of patients with the outcome of interest (sensitivity 98%). Second, the high risk variables identified by the rule makes clinical sense as being predictive of requiring critical care interventions in patients with tICH. These variables previously have demonstrated to be prognostic in tICH.24, 25, 26, 27?and?28 Third, [http://en.wikipedia.org/wiki/Oxygenase Oxygenase] a significant proportion of patients with tICH (31%) were low risk by the clinical decision rule. This suggests that successful validation and implementation of this rule will have a broad impact with significant resource sparing.32 Prior studies have evaluated baseline characteristics to predict outcome in traumatic patients with tICH.33, 34?and?35 Trauma scoring systems including the ISS36 and the Revised Trauma Score (RTS)37 predict mortality and other functional outcomes28 but are not designed as an ICU triage tool as they are calculated after the patient is discharged.