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.. Table II. Mean KLF4 protein expression in normal and lung cancer tissues. Histological classification of the lung cancer tissues was performed in order to identify differential expression of KLF4 between NSCLC and SCLC and between each tumor type and normal tissue. The statistical analysis revealed a significant difference in KLF4 expression between NSCLC and SCLC samples (P[https://en.wikipedia.org/wiki/Itraconazole Itraconazole] was observed between stage [http://www.selleckchem.com/products/Verteporfin(Visudyne).html Verteporfin clinical trial] I and stages II, III and IV (P[http://www.selleckchem.com/products/Vandetanib.html this website] 4 expression by immunohistochemistry. Tissue sections with (A) 0, no staining, (B) 1+, mild staining, (C) 2+, moderate staining and (D) 3+, intense staining. Table III. Profile of Kr��ppel-like factor 4 protein expression in each tumor stage (cases per intensity of expression). Factors associated with KLF4 protein level In order to determine any correlation of KLF4 expression with age and gender, a statistical analysis was performed; KLF4 expression was not found to be significantly associated with age or gender. Discussion The identification of proteins or transcription factors with altered expression as a manifestation of human lung carcinogenesis is important in the discovery of biomarkers for early detection of lung cancer. Only a limited number of studies have analyzed the expression and role of KLF4 in lung cancer (16,23�C26). In the present study, we investigated the KLF4 protein expression in a series of human lung tumors and normal tissues. As a result, differential expression was observed between healthy tissue and each of the two major lung cancer types (normal vs. NSCLC and normal vs. SCLC) and also between NSCLC and SCLC. The protein expression level of KLF4 was significantly decreased in NSCLC compared with that in normal tissue, while significant overexpression was detected in SCLC, which represents the fast-growing nature of this type of lung cancer that is considered highly lethal.