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Notes: Significant difference between groups (p[https://en.wikipedia.org/wiki/Quinapyramine Quinapyramine] factor alpha; GCSF, granulocyte colony-stimulating factor; Flt3L, haemopoietic growth factor Flt3 ligand; GMCSF, granulocyte macrophage colony-stimulating factor; IFN, interferon; GRO, growth related oncogene; IL, interleukin; MCP, monocyte chemoattractant protein; MDC, macrophage derived chemokine; sCD40L, soluble CD40 ligand; IL-1ra, IL-1 receptor antagonist; IP-10, interferon gamma-induced protein 10; MIP, macrophage inflammatory protein; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor. Click here to view.(759K, tif) Click here to view.(302K, tif) Supplementary Table 1 The summary of cytokines studies in active IBDs. Acknowledgments The authors thank Anil Shanker for critical comments and suggestions. They also thank Jared Elzey, CRA, from [http://www.selleckchem.com/products/MS-275.html MS-275] the Meharry Research Concierge Services (supported by NIH grants U54MD007593 and UL1TR000445) for comments, suggestions, and language editing. Footnotes ACADEMIC EDITOR: Melpakkam Srinivas, Editor in Chief FUNDING: This work was funded by the following grants: NIH R21DK095186; 1UL1 RR024975-01; 2UL1 TR000445-06; 3U54 CA091408�C09S1; 5U54RR026140-03; S10RR0254970; R21DKO76704; G12MD007586; U54MD007593; and U54CA163069. The authors confirm that the funder had no influence over the study design, content of the article, or selection of this journal. COMPETING INTERESTS: Authors disclose no potential conflicts of interest. Paper subject to independent expert blind peer review by minimum of two reviewers. All editorial decisions made by independent academic editor. Upon submission manuscript was subject to anti-plagiarism scanning. Prior to publication all authors have given signed confirmation of agreement to article publication and compliance with all applicable ethical and legal requirements, including the accuracy of author and contributor information, disclosure of competing interests and funding sources, compliance with ethical requirements relating to human and animal study participants, and compliance [http://www.selleckchem.com/products/GDC-0449.html click here] with any copyright requirements of third parties. This journal is a member of the Committee on Publication Ethics (COPE). Author Contributions Study concept and design, acquisition of data, analysis and interpretation of data, statistical analysis, critical writing and drafting of manuscript: OYK. Material and technical support: JNM. Experimental work and analysis of data: STP. Biostatistical analysis and interpretation of data and writing the ��Statistical methods�� section of the manuscript: LW.