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All participants were subject to a clinical evaluation prior to and following the intervention, using the Berg Balance Scale (BBS) and the Timed Up and Go (TUG) test. A physical therapist, with 10 years of experience, administered the tests. Participants were briefed about the nature of the intervention prior to the evaluation. The BBS is widely used to assess static and dynamic balance capabilities [14]: scores range between 0 and 56, with higher scores indicating superior balance. The TUG measures the time required to perform the following actions: stand up from a chair; walk 3 m at a normal pace; and turn around, walk backwards, and sit down [15]. The TUG is commonly used to examine functional mobility and balance [16]. Evaluation of side effects and use issues [http://www.selleckchem.com/products/INCB18424.html INCB018424] during 3D ARS training [http://www.selleckchem.com/products/PF-2341066.html Selleckchem PF2341066] The Pittsburgh Rehabilitation Participation Scale (PRPS) was used to evaluate the interest and motivation of participants following each 3D ARS session [17]. PRPS scores range from 1 to 6, as follows: 1, patient refused to participate in any exercises; 2, patient did not participate in at least half of the exercises; 3, patient participated in most or all of the exercises, but did not exhibit maximal effort or complete the majority of the exercises, or required significant encouragement to complete the exercises; 4, patient participated in all exercises, exhibited a high degree of effort, and completed most but not all exercises and passively followed directions; 5, patient participated in and completed all exercises, demonstrated maximal effort, but passively followed directions; 6, patient participated in and completed all exercises, demonstrated maximal effort, and took an active interest in the exercises. [http://en.wikipedia.org/wiki/DYRK1B AZ191] Additionally, we assessed any side effects, such as dizziness, headache, falling, and joint pain, which might be related to participation in the 3D ARS training. Statistical analysis Data are presented as mean��standard deviation (SD), median, or range. The normality of the continuous variables was assessed using the Kolmogorov-Smirnov test. Normally distributed variables are presented as mean��SD. We used the paired t-test to assess changes in clinical values before and after sessions. Changes in the performance scale and kinematic values for each session were assessed using linear regression analysis; rate of change is presented as regression coefficients (B) and the standard error (SE). p