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They were provided with an appropriate size of Tubigrip and advised to wear it for 7 weeks. Randomisation was stratification for gender (male or female) only. Patients were allocated to one of the treatment groups using a randomisation code generated by the Department of Medical Statistics at UHSM and by opening a sequentially numbered sealed envelope stored in [http://www.selleckchem.com/products/GDC-0941.html Akt inhibitor] A&E. The findings on full clinical history and examination, focussed on the ankle injury, were recorded on a purpose-designed data entry form initially and at 4 and 8 weeks. At each time point, the patient completed SF12v2 and AOFAS questionnaires and a visual analogue pain score ranging from 0 to 100 (0?=?no pain, 100?=?excruciating pain). After removal of the ES or Tubigrip by the clinical staff, each patient was seen by [http://www.selleckchem.com/products/ldk378.html Ceritinib order] a member of the research team blinded to the treatment group. The circumference of the ankle at its narrowest point and the calf at its widest were measured in centimetres. The range of movement of the affected ankle was measured using a goniometer. These results were then expressed as a percentage of those from the contralateral uninjured limb. Finally, all patients underwent duplex Doppler imaging by an experienced vascular technician, also blinded to the treatment allocation, for any evidence of a DVT.16 The primary outcome measure was the difference in the QoL between the two groups, measured by SF12v2 (acute version). The secondary outcome was improvement in the functional outcome by the widely accepted American Orthopaedic Foot and Ankle Score (AOFAS) questionnaire, validated specifically for ankle injury.17?and?18 Power calculations were performed based on Short Form (36) Health Survey (SF-36) scores. The physical and mental component scores of the SF-36 are considered accurate [http://en.wikipedia.org/wiki/ARAF ARAF] enough to warrant the use of published norms for SF-36 summary measures. The mean general health score following ankle sprain was 70, with a standard deviation (SD) of 17.19?and?20 To be of clinical value, the study was powered to demonstrate a difference of at least 15 for the mean general SF-36 health score: this required 22 patients in each treatment arm to give an 80% power at the standard 0.05 significance level. Data were analysed using Statistical Package for Social Sciences (SPSS?) version 15 (SPSS, Chicago, IL, USA). A generalised estimating model with an AR(1) correlational structure was used to assess differences between the two groups over the study period. This analysis is more efficient than a simple repeated measures analysis of variance (ANOVA) and can be used if there are missing data for some time points. Answers such as the ��use of crutches, stairs, analgesia and back to work�� were analysed by an independent sample t-test with p?