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""Selective internal radiation therapy [http://www.selleckchem.com/products/Y-27632.html Selleck Y 27632] (SIRT) with yttrium-90 microspheres is a promising treatment modality in patients with either primary or metastatic liver tumours. It is usually recommended for patients with advanced disease who are not candidates for local ablation, surgical resection, liver transplantation (LT) or for patients who have failed other treatments.1 Since April 2007, 177 patients with unresectable and untransplantable HCC have been considered for SIRT at the General Surgery and Transplantation Center of the National Institute of Infectious Disease ��L. Spallanzani��. Treatment was conducted in cooperation with the Interventional Radiology and Nuclear Medicine Unit of the National Cancer Institute ��Regina Elena��. Eligibility for SIRT was reviewed by a multidisciplinary panel. Pre-LT screening included: a review of the patient's clinical history (age, risk factors, comorbidities), diagnostic imaging by MRI and CT, determination of the level of underlying liver disease according to Child�CPugh and Model for End Stage Liver Disease (MELD) and disease stage according to UNOS Tumor-Node-Metastases (TNM) and Barcelona Clinic Liver Cancer (BCLC) classifications. The Eastern Cooperative Oncology Group (ECOG) performance status was also assessed for each patient. Patients were considered eligible for SIRT if they presented with: preserved liver function with normal bilirubin, INR [https://en.wikipedia.org/wiki/Bepotastine bepotastine] Australia). All patients had pretreatment mesenteric angiography and 99Tc-macroaggregated albumin scanning for the assessment of non-target distribution of the 90Y microspheres and the embolisation of aberrant vessels. All patients were followed-up for toxicities and adverse events. During follow-up all patients were monitored by CT scans at 1 month and subsequently at 3-month intervals. Overall 36 of 177 patients with intermediate�Cadvanced stage (BCLC B and C), who received SIRT were considered possible candidates for LT. Patients were selected for LT based on: age [http://www.selleckchem.com/products/AZD2281(Olaparib).html DNA Damage inhibitor] considered for LT after SIRT, 19 were excluded from the LT programme due to drug or alcohol abuse, HIV infection beyond the LT criteria or disease progression. Of the remaining 17 patients, SIRT had been used to downstage 13 patients and as a bridging treatment for LT in 4 patients. Ten patients were treated with SIRT before being put on the LT waiting list and 7 patients received SIRT while on the waiting list because of tumor progression. Seven patients had a liver transplantation post-SIRT.