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In addition, a single-dose FF, but not FP significantly improved the PC20 AMP up to 26?h. This study was not designed to directly compare both active treatments. For this reason, we only analysed the difference between the effects of FF and FP against placebo. Nevertheless, our findings suggest that FF may [http://www.selleckchem.com/products/sis3.html this website] have a longer duration of action than FP, and this is compatible with earlier results from in vitro studies. For example, Salter et?al. (8) investigated the pharmacological properties of different corticosteroids (FF, FP, mometasone furoate and budesonide) in cultured human epithelial cells. When adding the different corticosteroids to the apical site of an epithelial cell monolayer, FF was more rapidly absorbed and reached a higher maximal level in these [http://www.selleckchem.com/products/azd3759.html selleck screening library] cells than FP, mometasone furoate and budesonide. Salter et?al. also demonstrated a slower rate of transport of FF out of epithelial cells than that seen with the other corticosteroids. In addition, Valotis et?al. (11) have investigated receptor binding kinetics for FF in human lung tissue resection material obtained from patients with bronchial carcinomas. They showed that while FF has a statistically significantly higher association rate constant for binding to the human lung glucocorticoid receptor than FP or mometasone furoate (MF), it exhibits a dissociation rate constant similar to FP and MF. This resulted in calculated relative receptor affinity values of 2989?��?135 for FF, 1775?��?130 for FP (P?[http://en.wikipedia.org/wiki/ATP12A ATP12A] is the case, it could have important clinical consequences, because once-daily dosing may improve patient compliance which is generally poor in asthma patients (12). Since the effect of a single dose of either FP or FF was investigated, it was decided to use a relatively high dose of 1000?��g. It could be argued that our results may have been different with lower doses. For this reason, it will be interesting to investigate the efficacy and duration of action of different doses of FF in future studies. We investigated the protective effect of FF and FP against the PC20 AMP at different time points after administration of a single dose. This model has previously been used to investigate both the efficacy and the duration of action of ICS. First, Ketchell et?al.