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Exemplarily, gradient echo images (magnitude, R2* and phase shift) are shown in Fig.?2. According to the position of the dissected tissue specimens, regions of interest (ROI) were outlined manually in a single slice of the first echo of the fast spin echo sequence, because this image series showed the best contrast between gray and white matter. Then, the outlined ROIs were transformed automatically to the registered R2*, phase shift and MTR images using an affine registration and transformation algorithm from FSL (Smith et al., 2004). Blood vessels in corpses usually contain deoxygenated blood that can lead to rapid MR signal decay in highly vascularized regions. For this reason, ROI analysis was done distantly from larger vessels. Therefore [http://en.wikipedia.org/wiki/ALG1 ALG1] and to prevent transformation induced partial volume effects, all ROIs were manually checked after automatic affine transformation. Image analysis was performed blinded to the results of the chemical analysis. All analyses were performed using STATISTICA 7.1 (StatSoft, Tulsa, USA) and a p-value [http://www.selleckchem.com/products/pd-1-pd-l1-inhibitor-3.html www.selleckchem.com/products/pd-1-pd-l1-inhibitor-3.html] of p?[http://www.selleckchem.com/products/740-y-p-pdgfr-740y-p.html 740 Y-P] of the regional analysis of relaxation rates, MTR and phase shifts are presented in detail in Table?1. The transverse relaxation rates R2 and R2* yielded only moderate differences between cortical gray matter and white matter. In contrast, the MTR and the phase shifts were substantially different in the cortical gray compared to the adjacent white matter regions. Most remarkably, the mean phase shift in all cortical gray matter regions was positive indicating that overall paramagnetic contributions to the bulk susceptibility are larger than their diamagnetic counterparts. Conversely, the mean phase shifts in white matter regions were all negative. It should be noted that the sign of the phase is vendor specific and therefore arbitrary. Herein, positive values denote paramagnetic while negative values denote diamagnetic shifts with respect to the resonance frequency of water. A total of 120 specimens from six brains were analyzed with inductively coupled plasma mass spectrometry, 48 from cortical gray matter and 72 from white matter. The wet tissue weight ranged between 0.1 and 1.5?g. Mean iron concentration was lower in the frontal cortex (26?��?6?mg/kg wet mass) than in frontal white matter (45?��?6?mg/kg wet mass) while occipital an inverse relation was found (cortical gray matter, 41?��?10 vs.