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05 was considered statistically significant. Differences of quantitative data between the two groups were tested using the Mann-Whitney U-test. Survival curves were calculated according to the Kaplan-Meier method. Fifty-six of the 423 patients were younger than 50 years of age at the onset of the disease. The median age was 45 years, and the youngest patient was 27 years old. The male : female ratio was 1.3:1. The 367 patients over the age of 50 years formed the reference group. The median age in this group was 68 years, and the oldest patient was 91 years old. The male to female ratio in this group was similar at 1.7:1 (p = 0.382). A distinction [https://en.wikipedia.org/wiki/CAPNS1 CAPNS1] was made between the absence and presence of symptoms. Further differentiation was made according to pain, bleeding and clinical signs of B-symptoms. It was noticeable that in general the patients below the age of 50 complained of symptoms more frequently than the older reference group. Only 2% of the young patients reported having no symptoms at all beforehand, compared with 7% (p > 0.05) in the reference group. As regards the type of symptoms, there are only small and insignificant differences in the percentage distributions between the two groups. For instance, 13% of the younger patients had melaena or bleeding, compared with 14% of the older patients. Pain was reported by 38% of the under-50 year old patients, and 29% of patients in the reference group. The frequency of B-symptoms was similar in the two groups, at 47% and 50%, respectively. In the analysis, an attempt was made to combine certain symptoms into groups. Naturally, there were also patients with several symptoms (Tab. 1). In the [http://www.selleckchem.com/products/bmn-673.html Talazoparib chemical structure] under-50-year old patients, the tumor was located in the cardia/fundus region in 28% of cases, in the body in 28%, and in the antrum/pylorus in 42%. The entire stomach was involved in 2% of cases. The figures were similar in the reference group. Cancers were located in the proximal part of the stomach in 25% of cases, 28% in the body, and 39% in the distal part. Carcinoma involving the entire stomach was present in 8%. The stage distribution was similar in both groups. The relatively small percentage of stage IV cancers (25%) in the under-50 [http://www.selleckchem.com/products/s-gsk1349572.html Dolutegravir cost] patients is striking, but this is explained by the fact that we did not include patients who had prior neoadjuvant or adjuvant treatment. If these patients had been included, we would have obtained a very high proportion at 37%. In general, it can be stated that the stage distribution does not differ significantly (p = 0.93) and is similar. The diffuse type in the Laur��n classification, in contrast, presents significantly more often in the young patients at 77% compared with 49% (p