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We used rSVC flow as a surrogate marker of CBF, based on the assumption that the fraction of total brain perfusion to total SVC flow is of limited variation between newborn infants. FOE=(SaO2?SvO2)/SaO2FOE=(SaO2?SvO2)/SaO2 CMRO2 index?=?1.34?tHb?10?2?rSVC flow?(SaO2???SvO2)CMRO2 index?=?1.34?tHb?10?2?rSVC flow?SaO2???SvO2where 1.34?(mL), oxygen-binding capacity of haemoglobin per g. Gestational age, body weight, postnatal age, head circumference at the time of the study, and tHb assessed within 3 days of the study were obtained from the patient's record. Exploratory analysis was first performed to understand characteristics of the variables. Temperature values were compared between different sites using the paired t-test. Linear regression analysis was used [http://www.selleckchem.com/products/frax597.html FRAX597 cost] [http://www.selleckchem.com/Bcl-2.html see more] to assess (i) dependence of variables on the postnatal/postconceptional age and body weight, (ii) relationships between temperature values, and (iii) relationships among rSVC flow, the CMRO2 index, and CBV. The p values obtained from this exploratory analysis were corrected for multiple comparisons using Bonferroni correction. Primary analysis was then performed using univariate linear regression analysis, where dependence of temperature on rSVC flow, the TOI, CBV, FOE, and the CMRO2 index were assessed. For multivariate models, which explained the temperature, we assigned up to four independent variables based on (i) our hypothesis that body/brain temperature is determined by cerebral perfusion and metabolism (the CMRO2 index was not included because of significant collinearity with rSVC flow), and (ii) the results of univariate analysis (independent variables with uncorrected p values [https://en.wikipedia.org/wiki/Isoxsuprine Isoxsuprine] (both p?