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Finally, the influence of the lens status was compensated for by analyzing the differences between the green and blue components before calculating the Hb content. The blue, green, and red [http://www.selleckchem.com/screening/protease-inhibitor-library.html screening assay] components were assessed using an image analysis program with the Matlab image processing toolbox (The MathWorks, Inc., Natick, Massachusetts). Figure 1 A papillary image was divided automatically by the Laguna ONhE (optic nerve head hemoglobin) device into eight 45�� radial sectors and two concentric rings comprising 1/3 and 2/3 of the disc radius. The Laguna ONhE program analyzed the amount of ... 2.4. Statistical Analysis This was an observational, prospective cross-sectional study. All data analyses were performed using SPSS software version 20.0 (SPSS Incorporation, Chicago, Illinois) statistical software. The Kolmogorov-Smirnov test was used to assess sample distribution. Given the normal distribution of the data, the OCT and Hb parameters between healthy and PD patients were compared using Student's t-test with Bonferroni correction for multiple comparison, and correlations were examined by Pearson's test. Correlations between optic disc Hb percentages and disease severity (assessed by the Hoehn-Yahr stages) were also analyzed in the PD group by Pearson's test. 3. Results Epidemiologic and disease characteristics of patients with PD and healthy subjects are shown in Table 1. Mean age in the PD patient group was 67.3 years (range: 54�C80) and in the healthy control group 67.2 years (range: 55�C79). Intraocular pressure did not differ significantly between groups (P = 0.478). The duration [http://www.selleckchem.com/products/bgj398-nvp-bgj398.html learn more] of PD ranged from 2 to 19 years, with a mean of 8.5 years since diagnosis. The mean Hoehn-Yahr score was 2.68. The most frequent Hoehn-Yahr stages were stage 2 (56 patients) and stage 3 (41 patients), and mean Schwab-England ADL score was 44.05%. BCVA differed significantly between groups (0.95 in healthy controls, 0.74 in PD patients; P [http://en.wikipedia.org/wiki/Unoprostone Unoprostone] different treatment groups: dopamine-enhancers (most common), dopamine agonists, and other drugs (such as anticholinergics and amantadine). We included 10 de novo patients (without medication). Table 1 Epidemiologic and disease characteristics of 155 patients with Parkinson's disease and 91 healthy subjects included in the study and statistical significance of comparison between both groups (P). Mean Hb percentage and Hb content in sectors 3, 5, 8, 9, 12, 15, 19, and 21 (which mostly correspond with the outer ring of the papilla) calculated by the Laguna ONhE program were significantly lower in PD patients than in healthy controls (t-test with Bonferroni correction, P