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The Allergy Section of the Laboratory of Clinical Biochemistry, Haukeland University Hospital, analyses the serum samples for tryptase, IgE and IgE antibodies (Phadia AB) to a panel of relevant allergens including SUX. The study was approved by the Regional Committee for Medical Research Ethics in Western Norway. Variations in percentage of samples with elevated (>120?kU/l) and high (>5000?kU/l) levels of IgE by year were calculated by negative binomial regression with log link to test relative risk (RR). ��Before�� was used as [http://www.selleckchem.com/products/lee011.html Ribociclib manufacturer] reference group. Relative risk was adjusted for gender, age and month of analysis. Linear trend for adjusted RR by year was tested. Time trends of IgE-sensitization to PHO, MOR and SUX and reported suspected anaphylactic reactions were calculated by negative binomial regression with log link. For tables comprising cells with few numbers, linear trend was also calculated by exact methods in cross-tables. In the analyses, the total number of general anaesthesias per year is set to 200?000. Association between PHO and MOR, SUX and IgE were tested by linear regression analysis. All statistical analysis was performed by Statistical Package for the Social Science 17, (SPSS Inc 2008, Chicago, Illinois, USA). The impact of PHO exposure on IgE-sensitization in the three subpopulations of ��Allergics�� when compared with blood donors is summarized in Table?1. Percentages of sera with IgE antibody levels above cut-off (��0.35?kUA/l) to MOR, PHO and SUX [https://en.wikipedia.org/wiki/Otenabant Otenabant] are considerable among ��Allergics��. Most notably, in the two allergic populations, medium (M) and high (H), as many as 1/3 and 3/4, respectively, were IgE-sensitized to PHO. IgE-sensitization to SUX, i.e. to the QAI, rose from 3.7% among general ��Allergics�� to 12.0% and 30.6%, respectively, in the M and H groups. Sensitization is also clearly present among blood donors, where 6% carry IgE antibodies to PHO and 0.4% to SUX. Although there is a clear association between IgE sensitization to MOR and SUX in all groups, between 46% and 93% of positive still do not show antibody binding to QAI/SUX. The principle associations between IgE antibodies to PHO, MOR and SUX are exemplified [http://www.selleckchem.com/products/mi-773-sar405838.html check details] by group M data. The plotted individual antibody levels show a significant, linear relationship between PHO and MOR (gradient of regression 1.35; P?