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019). This was obvious in both genders, but reached statistical significance only amongst boys (P?=?0.016) ( Fig. 1). There was a 4.4-fold (95% CI 2.0�C10.8; P?[http://www.selleckchem.com/products/AZD0530.html Saracatinib solubility dmso] incidence of the injuries in organised sports, but it did not reach statistical significance (P?=?0.26). No change was observed in the incidence of tumbling (22%), falling between planes (21%), injury in a playground device other than trampoline (14%) or in traffic accidents (7%). ( Table 1) As many as 159 cases of all (94.6%) diaphyseal both-bone forearm fractures were treated in the operating room under general anaesthesia. There was a significant increase in the incidence of open reduction during the study time (from 2, 13.3% in 2000�C2001 to 29, 52.7% in 2008�C2009, P?=?0.015). At the end of the study phase (2008�C2009), no differences in the proportions of invasive treatment (52.7%) and non-invasive treatment were noted (P?=?0.57) ( Table 2). The incidence of the loss of reduction and the need of unplanned reduction was 29.9% (N?=?29/97) amongst the [http://en.wikipedia.org/wiki/SKAP1 SKAP1] [http://www.selleckchem.com/products/CAL-101.html CAL 101] cases that were treated non-invasively primarily. By contrast, the worsening of the reduction was observed in one case with internal fixation (1.4%, N?=?1/71) (P?