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We thank all the Newcastle Thousand Family Study members for taking part in this study and the study teams past and present, particularly Professors Alan Craft and George Alberti, who along with Professor Louise Parker, led the age 49�C51 year follow-up, and Emma Thompson who provides the administrative support for the study. We thank the previous funding bodies who have contributed to this study since it began. The preliminary data analyses for this paper were done during a Research Exchange visit by MSP to the University of Otago, funded by the British [http://www.selleckchem.com/products/BMS-777607.html find more] Council with further funding contributed by Breathe North. ""5064"	" In this occasional series we record views and personal experience of people who have specially contributed to the evolution of ideas in the Journal's field of interest. In a research area of daunting complexity, Deborah Dawson has made outstanding contributions to the evolution of ideas and meeting the needs for exact measurement, operational definition and insightful statistical handling1. A (Addiction): You have worked as an alcohol [http://en.wikipedia.org/wiki/RVX_208 RVX-208] epidemiologist for about 20 years, a span that has produced profound changes in US and international views of alcohol use, misuse and disorders. How would you summarize those changes? DD (Deborah Dawson): Research during the past 20 years has posed occasional challenges to some of our most deeply held beliefs about the relationship of alcohol consumption to harm and its public policy implications. For example, the purported benefits of moderate drinking [http://www.selleckchem.com/products/Neratinib(HKI-272).html Neratinib] for heart health have come under increasing scrutiny, with some findings suggesting that the well-known J-shaped curve is an artifact of an inappropriate referent category or failure to adjust for all of the behaviors and socio-economic advantages that characterize moderate drinkers (e.g. [1]). This debate has major ramifications for the role of alcohol in the global burden of disease as well as for alcohol policy. In addition, recent sporadic evidence of diverging trends in alcohol availability, consumption and harm (e.g. [2]) has raised questions about the validity of the total consumption model, which holds that reductions in heavy drinking and alcohol-related harm are best achieved through broad-based controls on the price and availability of alcohol. Challenges such as these do not mean that we have to abandon the total consumption model or the possibility of health benefits associated with moderate drinking, but they demonstrate the risks of complacency and uncritical acceptance of the status quo, and they underscore the benefits of developing alternative paradigms.