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This cross-sectional item-reduction study was conducted in 15 allergy or respiratory outpatient clinics, mostly hospital based, from the Portuguese regions of Norte, Centro, Lisboa, Alentejo and A?ores. At each centre, several physicians could participate and were asked to include at least eight patients each. The study was conducted in the last trimester of 2008. [https://en.wikipedia.org/wiki/Fleroxacin Fleroxacin] To ensure a broad usage of the questionnaire, all patients between 18 and 70?years of age, with a medical diagnosis of asthma and allergic rhinitis and at least 6?months of follow-up at the clinic, were eligible. The study was approved by the local ethics committee, and each patient gave his/her written informed consent. In addition [http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html CHIR 99021] to CARAT17, data collection included instruments to assess control and quality of life, as well as a medical evaluation. Regarding control, patients answered the Asthma Control Questionnaire (ACQ5) (10) and three visual analogue scales (VAS) concerning the presence of any airways symptoms, bronchial symptoms and nasal symptoms. Health-related quality of life was assessed by the EuroQol Questionnaire (EQ-5D) (14). The medical evaluation was carried out by the attending physician, who was blinded to the results of the questionnaires. The physician registered the patient��s rhinitis severity and control, asthma severity and control, known allergies and current medication (data not shown), as well as his decision regarding treatment (increase, maintain or decrease treatment). The population was described using standard descriptive statistical techniques. The statistical analysis was carried out using spss 17.0 (SPSS Inc., Chicago, IL, USA). The level of significance was set at P?[http://www.selleckchem.com/products/Y-27632.html Y-27632 cost] variable; considerable cross-loading (>0.300 in more than one factor); low item-total correlation (