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The objective of the present study was to provide a histologic account of crestal bone levels and mucosal profile at implant sites receiving platform shift/switch and standard abutments following conventional flap surgery and subcrestal implant placement in presence or absence of crestal gap defects using a dog model. Four dental implants were placed into the left/right edentulated posterior mandible in five adult male Hound Labrador mongrel dogs using flap surgery including subcrestal placement with/without a 1?��?5?mm (width �� depth) gap defect, and using platform shift/switch and standard abutments. Block biopsies were collected for histological/histometric analysis following an 8-week healing interval. No significant differences in crestal resorption were observed among experimental groups; crestal resorption being significantly more advanced at buccal than at lingual sites (p?[http://www.selleckchem.com/products/Adriamycin.html Doxorubicin chemical structure] crestal bone-implant contact was not significantly different among groups; crestal bone-implant contact being consistently below [http://en.wikipedia.org/wiki/FARP1 FARP1] the implant platform at buccal sites (p?[http://www.selleckchem.com/products/obeticholic-acid.html Obeticholic Acid] solution, and the defects were filled with bone graft and doxycycline powder. Bioabsorbable membranes were used. Final crowns were placed after 6 months. The patients were followed for an average of 30 months. Results: The surgical sites healed without complication. At the time of loading, the defects were completely restored. At 12 months postloading, there was crestal bone loss to the level of the first thread (average, 1.3?mm). Pocket depths ranged from 3 to 5?mm (average, 3.6?mm) with no bleeding. No further changes were noticed throughout the remaining follow-up visits.