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Motor balance tests were performed as described (Ji et?al., 2006). The bar catalepsy test was conducted immediately after the elevated-plus-maze test. The forepaws of rats were placed on a 1-cm-diameter bar fixed horizontally at 10?cm from the bench surface for a maximum of 10 s, during which the time (in seconds) for the animal to remove both forepaws was recorded. Balance and locomotor deficits were assessed on an elevated beam-walking test. One day prior to Tat-GluR2 injection, rats were trained to traverse the elevated wooden beam of 3.0-cm width and 1-m length from the open end to the darkened reward box. The following [http://www.selleckchem.com/products/pd-0332991-palbociclib-isethionate.html www.selleckchem.com/products/pd-0332991-palbociclib-isethionate.html] day after the bar catalepsy test, the time for rats to traverse the beam or falling was assessed in 5 separate trials. Results were reported as mean �� SEM. Statistical analysis of the data was performed using a student t test, square Chi test, one-way ANOVA, two-way ANOVA or two-way ANOVA for repeated-measures, followed by Bonferronni post-hoc test. Statistical significance was set at p?[http://www.selleckchem.com/products/Trichostatin-A.html TSA HDAC mouse] obtained with the NIH grant DA011322, as well as J. Rubenstein, M. Ekker, K.?Nave, and F. Kirchhoff for providing the Cre-expressing mice used to generate conditional mutant mice. Support from China-Canada Joint Research grant (to L. Xu and X.Z.), The Basque Country Government grant (GIC07/70-IT-432-07, to P.G.), Ministerio de Ciencia e Innovaci��n (SAF2009-07065, to P.G.), Red de Trastornos Adictivos, RETICS, Instituto de Salud Carlos III, MICINN (RD07/0001/2001, to P.G.), NIH grants (DA024741, to Q.L.; NS38077, to G.B.), grants from National Natural Science Foundation of China (NNSFC, 30725019, 81030021, to W.W.), 973 Progress (2009CB941300, to L.?Xu), NNSFC for distinguished young scholars (30725039, to L.X.), Major Program of NNSFC (30930091, [http://en.wikipedia.org/wiki/PTEN_(gene) PTEN] to L.X.), National High Technology Research and Development Program of China (863, 2007AA02Z310, to W.R.), INSERM/Avenir (to G.M.), INSERM (to D.N.A.), European Research Council (ERC-2010-StG-260515, to G.M.), EU-FP7 (REPROBESITY, HEALTH-F2-2008-223713, to G.M.), Fondation pour la Recherche Medicale (to G.M.), Region Aquitaine (to M.M.-L., G.M., and D.N.A.), Canadian Institutes of Health Research (to X.Z.), Natural Sciences and Engineering Research Council of Canada (to X.Z.), Cheung Kong Scholar (Chang Jiang Scholar) Award (to X.Z.