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001) (Table 5), whereas the GC and GG genotypes of rs1809442 were positively associated with the prevalence of the allergic symptoms (P[http://en.wikipedia.org/wiki/Alkaline_phosphatase (-)-p-Bromotetramisole Oxalate] especially nasal symptom, which were 4-fold increases in comparison to the heterozygous genotypes. Table 5 Comparison the odds ratios of allergic symptoms of 2 SNPs in the MD-2 gene promoter region among different genotypes (n=280) DISCUSSION Sensitization to the house dust mite D. pteronyssinus is a considerable risk factor for the progression of allergic diseases, such as asthma, rhinitis, and dermatitis.23 [http://www.selleckchem.com/products/JNJ-26481585.html JNJ-26481585 chemical structure] Recently, several large-scale genomewide association studies have been conducted to identify susceptibility loci for asthma, and their results showed an associated locus on chromosome 17q21 embodying the genes ORMDL3, GSDMB, and ZPBP2.24 Genome-wide associations between asthma and SNPs have also been observed in rs3771166 (IL1RL1/IL18R1), rs9273349 (HLA-DQ), rs1342326 (IL-33), rs744910 (SMAD3), and rs2284033 (IL2RB).25 Three SNPs (rs7775228, rs2155219, and rs17513503) at different loci have been identified in a genomewide meta-analysis, which are significantly associated with the risk of allergic and grass sensitization.26 Furthermore, 3 SNPs (rs3918392, rs528557, and rs2787093) in the ADAM33 gene have been reported to be significantly associated with mite-sensitized [http://www.selleckchem.com/products/ipi-145-ink1197.html selleck inhibitor] persistent allergic rhinitis.27 Despite the genomewide meta-analysis studies of genetic variants associated with allergic rhinitis and mite sensitization, no research has focused on interactions between mite sensitization and SNPs in the MD-2 promoter region. In this study, 6 SNPs in the proximal promoter region of the MD-2 gene were analyzed, and 2 SNPs (rs1809441 and rs1809442) in the MD-2 promoter region had statistically significant differences between D. pteronyssinus-allergic patients and healthy controls when the genotypes and allele frequencies were compared. These 2 SNPs of the MD-2 promoter were associated with the presence of high levels of D. pteronyssinus- and Der p 2-specific IgE in the sera of the mite allergy group. Significant associations were also observed between the 2 SNPs of the MD-2 promoter region and high expressions of Der p 2 allergy characteristics, such as Der p 2-specific IgE and Der p 2-activated B cells, in allergic patients. These results suggest that these SNPs in the promoter regions may indicate genes that are susceptible to allergic inflammation caused by D. pteronyssinus, and supports the hypothesis that genetic polymorphisms in the MD-2 promoter region significantly contribute to susceptibility to Der p 2 allergy.