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e. a decrease in blood pressure of 40 mm Hg (systolic) or 20 mm Hg (diastolic) within 15 s of standing] was related to falls and frailty, while orthostatic hypotension according to the consensus definition [22] was not. Strengths and Limitations The mean age was >70 years, both groups were without cardiovascular disease, and no one used antihypertensive drugs. These are considered important strengths of our design. The main limitation is the small patient group �C and, ideally, all participants should have been free from all types of medication. Some of the patients used ChEIs and/or psychotropic drugs, mainly SSRIs. ChEIs can reduce HRV, but HF more than LF power [37]. In a recent study, patients were tested before and under treatment with ChEIs: the medication increased the LF/HF ratio and reduced HF power, but it did not influence the occurrence [http://www.selleckchem.com/products/Staurosporine.html Smad inhibitor] of orthostatic hypotension [38]. The use of ChEIs in our sample is therefore prone to diminish the differences rather than exaggerate them. SSRIs can cause orthostatic hypotension, but the patient group did not differ in any of the hemodynamic variables. Conclusion Orthostatic blood pressures and other hemodynamic variables did not differ between healthy controls and patients [http://www.selleckchem.com/products/dorsomorphin-2hcl.html Dorsomorphin molecular weight] with MCI or mild AD without cardiovascular disease and antihypertensive treatment. The findings of decreased LF power and LF/HF ratio of HRV in the patient group during tilt, together with a larger decrease in LF power of BPV, suggest a poorer sympathetic response to orthostatic challenge in AD. Acknowledgment This work was supported by the Oslo University Hospital.""The Montreal Cognitive Assessment (MoCA) is a 10- to 20-min screening test designed to assist clinicians in detecting early or minor cognitive impairment [1]. Performance on the MoCA has been demonstrated to be dependent on the educational level. The initial 1-point correction for ��12 years of education, suggested by Nasreddine et al. [1], was derived from a validation sample residing in [http://en.wikipedia.org/wiki/Resminostat Resminostat] Montreal with a mean educational level of approximately 12 years. More recently, in recognition of the necessity for further score correction in individuals with a lower education, the same group recommended a revised correction of +1 point for 10-12 years of education and +2 points for 4-9 years of education [2]. No score adjustment was suggested for those with