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The specimens were then divided into four groups (n?=?6) according to framework material (titanium or zirconia) [http://en.wikipedia.org/wiki/Fluconazole Fluconazole] and retention method for the prosthesis (cement- or screw-retained): G1, Ti-cemented; G2, Ti-screw-retained; G3, Zr-cemented; and G4, Zr-screw-retained. A digital torque ratchet was used to assess the initial preload removal torque. Torque was then reapplied and the specimens were submitted to a 200?N cyclic load, at a frequency of 2?Hz, underwater in controlled temperature of 37��, and for 1?��?106 cycles. An opposing lower dental arch was fabricated using bis-acrylic resin to simulate occlusal contacts in centric. After cyclic loading, postload removal torque was measured. Preload and postload torque loss was expressed as a percentage of the initial load. Data were submitted to a linear mixed-effects model for statistical significance (��?=?0.05) to evaluate the effect of cyclic loading in the screw torque loss used with frameworks of different materials and retention methods. Significant screw torque loss (%) was found for the tested groups (before/after cyclic loading, respectively): [http://www.selleckchem.com/ALK.html ALK cancer] G1 (39.77/61.83), G2 (37.57/50.96), G3 (34.87/54.10), and G4 (47.56/73.50) (P?[http://www.selleckchem.com/products/AG-014699.html Rucaparib cost] has been developed. With this system, it is possible to spray fine particles and to apply textured hydroxylapatite coatings onto titanium surfaces. Moreover, due to the low heat power of the microplasma jet, overheating of the powder particles as well as excessive local overheating of the substrate is diminished. Furthermore, because of the small laminar plasma jet, it is possible to achieve high spray efficiency in the case of spraying for dental implants. Also, the low level of noise (25�C50?dB) and hardly any dust makes it possible to operate MSE under conditions of normal workrooms. Objective: The aim was to investigate, in a mandibular dog model, bone biological properties and the occlusal loading effects of titanium implants provided with newly developed microplasma-sprayed CaP coatings. Material and methods: For histomorphometrical evaluation, 48 screw-type titanium implants were inserted into the mandibles of six adult beagle dogs. The implants were either acid etched without additional coating, coated with a conventionally plasma-sprayed CaP ceramic, coated with a microplasma-sprayed CaP ceramic or with a microplasma-sprayed coating at the apical part only. To assess the effect of occlusal loading, a split-mouth design was used.