Перегляд вихідного коду сторінки Get Rid Of AP24534 Complications Directly

Coyne avec 's. [15] examined data via a few future, randomized, placebo-controlled trials and discovered that will 91% involving sufferers given dental paricalcitol arrived at 2 straight reductions in iPTH levels of ��30% compared to 13% of placebo patients (G [http://en.wikipedia.org/wiki/MERTK UNC2881] �was not� �significantly� �different� �between the two� �groups�. �A study� �by� Kovesdy �et� �al�. [16], �comparing� paricalcitol �and� ergocalciferol, �found that� paricalcitol �was� �more effective� �at� �decreasing� iPTH �levels� �with no� �difference in� �the� �episodes of� hypercalcaemia �and� hyperphosphataemia. S��nchez �et� �al�. [17], �in a� retrospective observational �study� �performed� �under� �routine� �clinical� �practice� �conditions� �similar to� �ours�, �found that� �the main objective� �of the� �study� (�two� �consecutive� iPTH �reductions� �of� 30% �from� �baseline�) �were� �achieved� �in� 54% �of the� �treated� �patients�. �Mean� �Ca� �and� �P� �variations� �during this� �study� �were� �also� �not� �significant�. �A significant� �decrease of� �44�.9% �in� �mean� iPTH �from� �baseline� �to the� �end� �of the� �study� �was� �noticed in� �our group�. Coyne �et� �al�. [15] �found� �a similar� iPTH �decrease in� �the� paricalcitol �groups� �they� �analysed� �with a� �maximum� �mean� �decrease of� �45�.2%. �In our� �study�, �the greater� iPTH �reduction� �during� �treatment� �was found� �between� �baseline� �and� �first� �month�. �This is� �in agreement� [http://www.selleckchem.com/products/Imatinib-Mesylate.html STI571 solubility dmso] �with� �previous� �studies� �in� CKD �stage� �3� �and� �4�, �as well as in� dialysis, �patients� �showing� �that the� �major� �decrease in� iPTH �levels� �occurred in� �the first� �1 to 2� �months� �of� �treatment� �with� �less� �effect� �thereafter� [15�C17]. �Although� vitamin-D metabolites �have shown� �proven� �efficacy� �at� �achieving� �suppression� �of� �elevated� iPTH �levels� �in� CKD �patients�, hypercalcaemia �and� hyperphosphataemia �frequently� �complicated� [http://www.selleckchem.com/products/AP24534.html AP24534 molecular weight] �their� �use�. �A high� �Ca� �� �P� �product� predisposes �to� extraosseous calcifications, �including� �arteries� �and� �cardiac� valves, �associated with� �high� �morbidity� �and� �mortality� [18]. Bianchi �et� �al�. [19], �using a� �constant� calcitriol �dosage� �of� �0�.�25� �and� �500� mg/day �of� �calcium� carbonate �noted� �an� �increment� �of� �serum� �Ca� �levels� �from a� �baseline� �value of� �8�.�5� �� �0�.�3� �to� �9�.�9� �� �0�.�2� mg/dL. Ritz �et� �al�. [20] �reported� �no� �change in� �serum� �Ca� �levels� �with a� �daily� calcitriol �dose� �of� �0�.�125� ��g, �but� iPTH �levels� �also� �remained� �unchanged�. Hamdy �et� �al�. [21], �in a� placebo-controlled �trial�, �showed that� alfacalcidol �significantly� �increased� �the� �mean� �serum� �Ca� �levels� �in� �patients� �with� mild-to-moderate CKD �after� �4 weeks� �of� �treatment� �and this� �change� �persisted� �until the end� �of the� �study� (�24 months�). �It is� �well established� �that� �selective� VDRs �activation� �with� paricalcitol �decreases the� �intestinal� �absorption� �of� �Ca� �and� �P� �and� �diminishes� �the risk of� hypercalcaemia �and� hyperphosphataemia [3]. �In� Coyne's �analysis�, �the� �incidence� �of� hypercalcaemia, hyperphosphataemia �and� �elevated� �Ca� �� �P� �product� �was not� �significantly� �different� �between� �patients� �treated with� paricalcitol �and� placebo [15]. �Similarly�, �in� S��nchez's �study� [17], �among� �92� �patients� �who� �completed� �a� 6-month �treatment� �period�, �only� �5� (�5�.4%) �showed� �serum� �Ca� �levels� >10.