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2%) (��2?=?17.00, p?[http://www.selleckchem.com/products/r428.html R428 cell line] with primary (64.1%; 95% CI, 57.7�C70.0%) and secondary syphilis (56.3%; 95%CI, 48.5�C63.7%) (��2?=?2.109, p 0.146). Of the 238 PCR-positive specimens, 211 (88.7%; 95% CI, 84.0�C92.1%) were successfully subjected to restriction-digestion analysis. Overall, two hundred and eleven of the 391 patients with early syphilis were positive by PCR, with an overall positive rate of 54.0%. The demographic and behavioural characteristics, the clinical and laboratory syphilis data and the HIV status for the 211 patients who were finally included for analysis of the resistance are summarized in Table?1. Specifically, out of the 211 patients ranging in age from 19.6 to 57.9?years (mean, 30.1?years), 161 (76.3%) were male and 50 (23.7%) had been married. Of the 96 patients with known HIV status, one (1.0%) was positive for HIV infection. Of the 136 patients who reported sexual orientation, two (1.3%) were men who had anal sex with other men. Of the 211 patients with syphilis, 140 (66.4%) were diagnosed with primary syphilis and 71 (33.6%) with secondary syphilis. Of [http://www.selleckchem.com/products/jq1.html buy JQ1] the 155 patients who were aware of whether they had a history of exposure to macrolide antibiotics, 128 (82.6%) reported use of the antibiotics. The restriction-digestion analysis of the T.?pallidum 23S rRNA gene PCR amplicon showed that the A2058G mutation, conferring resistance to azithromycin, was present in 91.9% (194/211; 95% CI, 87.2�C95.1%) of specimens with amplifiable DNA from the study subjects, indicating no significant differences between the patients from the eastern part (93.8%; 95% CI, 86.4�C97.3%), southern part (88.6%; 95% CI, 80.3�C93.7%) and northern part (95.2%; 95% CI, 84.2�C98.7%) of China (��2?=?2.303, p 0.316). Compared with patients who had not taken macrolides in previous years before study entry, the patients [https://en.wikipedia.org/wiki/E-64 E-64] who had taken the antibiotics had a significantly higher prevalence of azithromycin resistance (97.0% vs. 62.5%). The relative risk of having the mutation was 19.65 (95% CI, 5.77�C66.93; p?