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1994; Cheng et al. 2011), which generates inward current that contributes to diastolic depolarization. Inhibitory effects of SR inhibition on AVN spontaneous rate/cycle length have also been seen in intact AVN tissue preparations from the rabbit, mouse and dog (Nikmaram et al. 2008; Kim et al. 2010). A recent study of the intact canine atrioventricular junction reported two experiments showing that [http://www.selleckchem.com/products/MLN8237.html selleck compound] ryanodine pretreatment markedly attenuates the positive chronotropic effect of the ��-adrenergic agonist isoprenaline (Kim et al. 2010). This is suggestive of a role for Ca2+ cycling in sympathetic modulation of AVN rate, though this requires validation through further experimentation. Whilst prior studies have investigated the effects of ryanodine on intact AVN preparations (Nikmaram et al. 2008; Kim et al. 2010), complementary data are lacking for inhibitors of SR Ca2+ uptake. In recent experiments involving measurement of [Ca2+]i from spontaneously [http://www.selleckchem.com/products/wnt-c59-c59.html C59 nmr] active AVN cells, exposure to CPA for [https://en.wikipedia.org/wiki/Aldosterone Aldosterone] filtered through a filter with 5?��m pore diameter. To investigate the spontaneous pacemaking activity of the AVN in the intact heart, surgical ablation of the SAN in the Langendorff-perfused heart was used to produce a model of the AVN-paced heart. Following the establishment of Langendorff perfusion, the heart exhibited regular beating driven by the SAN (at a rate of 166.8?��?5.4? beats min?1?n?=?10). The SAN was then excised from the right atrium by cutting from the top and along the border of the atrium. Tissue was carefully and progressively trimmed away until a sudden decrease of heart rate indicated that the SAN had been effectively removed and pacing had been taken over by the AVN.