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The WBV consisted of 15 consecutive frequency steps (12, 20, 30, �� to 150?Hz). Each of the 15 frequencies was applied for 2000 cycles, at an acceleration of 0.3?g. In the group with a 25-day healing period, PET images were taken at ?1 (day before surgery), 3, 5, 7, 10, 14 and 21 days of loading, after an injection of [18F]sodium fluoride, a positron-emitting tracer. The ratio of the metabolic activity around the implants to that of a reference site (uptake ratio) was calculated as a measure of bone metabolism. Bone-to-implant contact (BIC) and peri-implant bone fraction (BF) were analysed for histomorphometrical measurement. Results: The mean BIC and BF were significantly influenced by both the loading and the healing time (ANOVA, P[http://en.wikipedia.org/wiki/Isotretinoin Isotretinoin] and BF significantly. The results confirm the bone-stimulating potential of LMHF loading, through WBV, on peri-implant bone healing and osseointegration. To cite this article: Ogawa T, Zhang X, Naert I, Vermaelen P. Deroose CM, Sasaki K, Duyck J. The effect of whole-body vibration on peri-implant bone healing in rats. Clin. Oral Impl. Res. 22, 2011; 302�C307. doi: 10.1111/j.1600-0501.2010.02020.x ""M. Filius University Medical Center Groningen, Groningen, The Netherlands Background Treatment need is high in children with severe oligodontia and anodontia because they often suffer from functional and esthetic problems due missing teeth. [http://www.selleckchem.com/products/gdc-0068.html selleck] As the intraforaminal region barely grows after eruption of the permanent mandibular incisors, dental implant treatment [http://www.selleckchem.com/products/incb28060.html see more] is a considered treatment option in these children. Aim/Hypothesis To evaluate patient satisfaction and surgical and prosthetic care and aftercare related to the placement of two dental implants to retain mandibular overdentures in young children with severe oligodontia. Material and methods Four consecutive children (age 6 till 13?years) with no erupted teeth in the mandibula, suffering from functional and esthetic problems, were provided with an implant-retained overdenture on two dental implants. Surgical and prosthetic care and aftercare were scored. Finally, patient and parent satisfaction related to the implants and the overdenture was assessed at the end of the follow-up. Results Patients and clinical assessments: Median follow-up was 5.2?years (range 3.2�C8.4?years). Bleeding-index and probing depths were highest in patients with the longest follow-up. In all patients the esthetics improved after implant treatment. Complete dental arches were shown during smiling and the anterior face height also improved. Surgical and prosthetic aftercare: No implants were lost. Prosthetic aftercare was hardly needed. The number of visits for releasing sore spots or (de)activating retentions was low. In none of the patients changes occurred in the inter implant distance during growth of the individuals.