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2% vs. 42.7% respectively, P value?[http://en.wikipedia.org/wiki/Mannose-binding_protein-associated_serine_protease Mannose-binding protein-associated serine protease] injury, 40.2% among patients that arrived during the second day after the injury, and 41.5% among patients that arrived during the third day after the injury; however, this difference did not reach statistical significance (P value?=?0.05). Mortality rate was higher among patients without administration of pre-hospital fluids (52.4%) than among patients with pre-hospital fluids administered (P value?[http://www.selleckchem.com/products/MG132.html MG-132 purchase] among patients with admission GCS of 8 (19.5%) ( Table 1). In a multivariable logistic regression model adjusted for demographics, injury characteristics, and information at admission to the trauma centre, the odds of death among patients with hypothermia were 1.70 times the odds of death among patients with normothermia (OR 1.70, 95% CI 1.50�C1.93), indicating that the probability of death was significantly higher when patients arrived hypothermic [http://www.selleckchem.com/products/byl719.html Alpelisib price] at the trauma centre (Table 2). The assessment of interaction between admission hypothermia and sex was not found to be statistically significant and was not included (Likelihood ratio test's P value 0.077); sex differences in mortality were not statistically significantly different after severe TBI in hypothermic patients (OR, 0.87, 95% CI 0.68�C1.11) and in normothermic patients (OR, 1.11, 95% CI 0.98�C1.26). The final logistic regression model demonstrated an acceptable discrimination (AUC 0.792, 95% CI 0.784�C0.801), however calibration was not adequate (P value?