Перегляд вихідного коду сторінки Most Disregarded Fix For CASK

6?mm/s (a ~?15% drop), still considerably higher than without Intralipid. Thus the time window afforded by Intralipid injection (at least 60?min) is likely to be sufficient for most neuroimaging [http://www.selleckchem.com/products/cpi-637.html selleck chemicals] studies assessing physiological, pharmacologic and functional interventions. Moreover, for studies requiring longer time measurements, additional continuous slow infusion of Intralipid (e.g., 1?mg/kg/h to target a specific optimal concentration) can be implemented to correct for the decay due to clearance. Fig.?4 compares 3D ��OCA and ��ODT images of microcirculatory networks on the cortex of a mouse brain at baseline before (upper panels) and after Intralipid injection (lower panels). Panels (a�Cb) are [http://www.selleckchem.com/products/oicr-9429.html Epigenetics inhibitor] maximum-intensity-projection (MIP) images that show the micro-vasculature networks (��OCA) before and after Intralipid injection (6ml/kg, i.v.); Panels (c�Cd) are the MIP images in pseudocolor to show their quantitative CBFv distributions (��ODT). Panels (e�Cf) are the corresponding 3D ��ODT images to show the connectivity of the microcirculatory CBFv networks. The dramatic improvement with Intralipid injection is apparent when comparing the ��ODT images in panels (d, f) vs panels (c, e), in particular for flow detection in capillary beds. For instance, many of the ��apparently�� disconnected capillary flows (c�Ce), which were barely detectable, can be clearly traced as continuous flows with much stronger signals after Intralipid injection. To quantify these differences, we applied digital [http://en.wikipedia.org/wiki/CASK CASK] image processing (Supplementary Fig. s1) to segment the flow boundaries after excluding the regions occupied by large branch vessels. We defined the fill factor (i.e., # pixels occupied by capillaries/# pixels in the entire region excluding large vessels) to statistically assess the detectable capillaries (��OCA) and capillary flows (��ODT). Panel (g) shows that, while the fill factor of ��OCA increased significantly (17.5%; p?