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02.00 The chi-squared test, Fisher exact test, t-test and Mann�CWhitney test were used to compare the distribution of demographic and depression variables between cases and controls. The Mann�CWhitney test was used to compare frequencies of subject-based and teeth-based probing pocket depth and CAL ��?3, ��?4, ��?5 and ��?6?mm. Univariable and multivariable logistic regression models were used to measure [http://en.wikipedia.org/wiki/Unoprostone Unoprostone] the association between the outcome variable (chronic periodontitis, CAL ��?5?mm) and explanatory variables, which included age (>?35?years), gender, race, smoking (current or former), plaque (mean distribution frequency of teeth with PI ��?2 in ��?20% of the teeth), depression, MMD chronicity, MDD severity, MDD subtype and MMD (episode or disorder). Exposures with p?��?0.25 in the univariable model were included in the multivariable model. The odds ratios and corresponding 95% confidence intervals were calculated. Differences at the 5% level were considered statistically significant. A total of 112 individuals who initially met the inclusion criteria were prescreened. Twenty-seven were excluded after SCID because they were not available for periodontal [http://www.selleckchem.com/products/bgj398-nvp-bgj398.html selleck compound] examination, refused clinical periodontal examination, or presented another psychiatric disorder (bipolar disorder). After periodontal evaluation, 12 participants with MDD and one control were excluded. Seven patients were edentulous (six MMD and one control), and three suffered from bipolar disorder (had an episode of hypomania soon after taking antidepressants). Two patients were removed from the MDD group because of alteration in the blood test and fibromyalgia (Fig.?1). Ten patients underwent periodontal evaluation during remission of depression, and two patients at the end of psychiatric treatment (3�C4?mo later). PI and GI for the latter two patients were not included in the statistical analysis. The final sample consisted of 72 subjects (36 depression outpatients and 36 healthy controls), [http://www.selleckchem.com/screening/protease-inhibitor-library.html http://www.selleckchem.com/screening/protease-inhibitor-library.html] who completed the clinical periodontal examination and the psychiatric interview. Demographic and socioeconomic data of the 72 patients are summarized in Table?1. Employment status (p?