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The mean follow-up time for this sample of patients is of 5?years. All implants were clinically and radiologically monitored at each year follow-up and data regarding facial mucosa height (the distance between the gingival zenith and the incisal edge of the prosthetic restoration), buccal, mesial, distal and lingual/palatal probing depth and inter-proximal bone peak were collected. Buccal bone width (BBW) value was evaluated during surgery and was recorded after implant placement. Inter-proximal [http://www.selleckchem.com/screening/natural-product-library.html Natural Product Library] bone resorption was investigated by the use of individualized intra-oral RX tray, such to have always the same projection and measurements were acquired after setting 1?:?1 the images using the implant measures as a reference. All data were then inserted in a statistical software and processed. Afterwards the results were compared to those provided by the literature (an in-depth research was made through the PubMed and Google Scholar databases). Results The predictability of good profile about soft tissues is achieved by a simplified implant prosthetic protocol and an adequate prothesis design, progressing from healing abutment to definitive crown. After 3?years, soft [https://en.wikipedia.org/wiki/Aldosterone Aldosterone] tissue around implant doesn't show recession in comparison to soft tissue around adjacent molar that suffered recession. Conclusion and clinical implications An implant placement in the right position accompanied by a proper emergence profile prosthetic restoration gives a long predictability and ideal [http://www.selleckchem.com/products/cobimetinib-gdc-0973-rg7420.html Selleckchem GDC973] aesthetics of gingival line. Zenith level can be controlled with a proper emergence profile shaping. ""Objectives: The aim of this study was to analyse the influence of the microtopography and hydrophilicity of titanium (Ti) substrates on initial oral biofilm formation. Materials and methods: Nine bacterial species belonging to the normal oral microbiota, including: Aggregatibacter actinomycetemcomitans, Actinomyces israelii, Campylobacter rectus, Eikenella corrodens, Fusobacterium nucleatum, Parvimonas micra, Porphyromonas gingivalis, Prevotella intermedia, and Streptococcus sanguinis were tested on Ti surfaces: pretreatment (PT [Ra