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?commune was named Sch c 1; it was a homolog of glucoamylase. The IgG and IgE titres against Sch c 1 in patient sera were significantly higher than those in healthy volunteer sera (P?[http://www.selleckchem.com/products/z-vad-fmk.html Z-VAD-FMK cell line] shown to be an inducer of myeloid dendritic cells, Th2 responses, mast cells, and natural killer T cells, thereby leading to cytokine secretion and the development of AD. We hope that further understanding of the TSLP pathway and its role in the pathogenesis of AD will lead to improved clinical management of AD in the future. Cite this as: S. P. Jariwala, E. Abrams, A. Benson, J. Fodeman and T. Zheng, Clinical & Experimental Allergy, 2011 (41) 1515�C1520. ""Cluster immunotherapy represents an interesting alternative to conventional up-dosing schedules because it allows achieving the maintenance dose within a shorter time interval. In this study, the efficacy [http://www.selleckchem.com/products/ly2157299.html Galunisertib supplier] and safety of cluster immunotherapy with a high polymerized [http://en.wikipedia.org/wiki/RhoC RhoC] allergen extract of a grass/rye pollen mixture have been evaluated in a randomized, double-blind, placebo-controlled, multicenter study. In total, 121 patients with allergic rhinoconjunctivitis due to grass pollen were randomized 1?:?1 to verum or placebo group. A short cluster up-dosing schedule of only 1?week was applied to achieve the maintenance dose which was administered monthly during the study period of 1?year. Total combined symptom and medication score (TCS) was defined as primary outcome parameter. Secondary outcome parameters were individual symptom and medication scores, ��well days,�� global improvement as well as immunological effects and nasal allergen challenge. The safety profile was evaluated based on the European academy of allergy and clinical immunology grading system. Significant reduction in the verum compared to the placebo group (intention-to-treat, population, verum: n?=?55; placebo: n?=?47) was found regarding TCS (P?=?0.005), rhinoconjunctivitis total symptom score (RTSS, P?=?0.006), and total rescue medication score (TRMS, P?=?0.002). Additionally, secondary outcomes such as ��well days,�� nasal challenge results, and increase of specific IgG4 were in favor of the active treatment. All systemic adverse reactions (0.8% of all injections in the verum group) were of mild intensity. No severe reactions related to the study medication were observed.