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It is unlikely that this level of residual viraemia is responsible for the appearance of new mutations [8, 9], but one can speculate that persistent viral replication of archived variants may, over time, lead to changes in the mutational archive. A low level of replication may also occur in cells located in sanctuary sites, where drug levels [http://en.wikipedia.org/wiki/Histone_demethylase Histone demethylase] may be suboptimal [10, 11]. Furthermore, the modifications of HIV-1 DNA in the mutational archive may result from a redistribution towards the peripheral blood of ��drug-resistant�� infected memory CD4+ T-cells trapped in the lymphoid tissue [12]. Finally, we cannot rule out the possibility that, during follow-up, a decrease in the amount of the dominant archived viral variants may lead to variation in the detection of mutations. We firmly believe that a more realistic scenario is that all of the above circumstances coexist and contribute, in different ways and at different times, to the establishment and to the dynamic of the intracellular drug resistance pattern. Interestingly, the analysis of protease inhibitor RAMs revealed that 18 patients had intracellular mutations associated with darunavir/ritonavir resistance at T0; specifically, according to REGA rules [13], six of these 18 patients showed genotypic resistance to darunavir/ritonavir [http://www.selleckchem.com/products/abt-199.html Venetoclax datasheet] (score of ��3.5), eight had intermediate susceptibility (score of ��2 and [http://www.selleckchem.com/products/MDV3100.html Enzalutamide molecular weight]