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TEWL is affected by internal factors, such as body temperature, activity and metabolism, but also by external factors such as the environment humidity or temperature, which can mask the values and their interpretation. The aim of this work was to evaluate the circadian rhythm of the skin functions in an animal model such as hairless rats and determine their dependency on the environmental light and temperature. Also, we tested whether the skin variables could be dependent on the rhythmic pattern of [http://www.selleckchem.com/products/PD-0332991.html www.selleckchem.com/products/PD-0332991.html] the animal. We measured skin temperature, TEWL, SCH and motor activity levels of eight male hairless rats in six experimental days under different lighting conditions (Figure S1). In each experimental day, measures were obtained every 2?h for 24 consecutive hours under different environmental conditions (Figure S2). All data [https://en.wikipedia.org/wiki/Cilengitide Cilengitide] values were referred to the time of the subjective day (circadian time, CT). Thus, CT0 and CT12 corresponded, respectively, to the onset of the subjective day (rest) and subjective night (activity). To investigate the presence of circadian rhythms, data from each experimental day and variable were fitted to a sinusoidal function [10], providing the estimation of the amplitude of oscillation, expressed as a percentage of variation around the mean, and its acrophase (the time the adjusted curve reaches its highest value). Moreover, differences between the subjective day and night were calculated. Under constant light (LL), the circadian rhythms were lost and linear correlation between environmental temperature and skin variables was analysed. Methodology is described in Data S1. In all cases, nocturnal values were higher than diurnal (Fig.?1), excepting under LtD, where skin temperature and TEWL were higher during light, following the environmental temperature. Both SCH and TEWL increased the mean daily values throughout the days of the experiment when animals were rhythmic (linear regression, r2?=?0.8989 n?=?6, P?[http://www.selleckchem.com/products/Everolimus(RAD001).html check details] and r2?=?0.9179 n?=?6, P?