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Stand S6 Frequent (��1% or perhaps recognized possible complications) all-causality unfavorable activities by simply intensity (CTCAE v3) in line with the period of time from very first 90Y-RE method (day time 0) inside 606 patients System wood, course Evening Zero, D (Per-cent) Times 1-7, In (Per cent) Days and nights 8-90, And (Percent) Nights 91-184, N (%) Not known CTCAE grade 1-2 CTCAE level ��3 Not known CTCAE grade 1-2 CTCAE rank ��3 Unknown CTCAE level 1-2 CTCAE level ��3 Unknown CTCAE grade 1-2 CTCAE level ��3 Gastrointestinal 0 Fifty (8.Three or more) 6 (One particular.Only two) 1 (Zero.A couple of) 160 (Twenty three.A single) 18 (Only two.7) 2 (3.Three) 152 (Twenty-five.One) 39 (Some.Some) Three (3.Your five) 32 (5.Three or more) 10 (A single.Several) ????Abdominal pain 0 Thirty (Your five.Zero) Some (One.3) One (3.Only two) Ninety-six (15.7) Ten (1.7) Two (Zero.Several) 114 (16.8) Twenty two (Three.Six) 3 12 (Three.Eight) 5 (0.8-10) ????Nausea 2 Thirty (5.0) 2 (3.3) Only two (3.3) Seventy six (14.Your five) 3 (0.5) Only two (Zero.Three or more) Sixty-five (Ten.7) Three or more (Zero.5) One particular (0.Two) 10 (1.6) One particular (Zero.A couple of) ????Vomiting 3 Nine (A single.Five) 2 [http://en.wikipedia.org/wiki/Farnesoid_x_receptor FXR] 0 Twenty (3.3) Your five (Zero.8) 2 Thirty-one (A few.A single) Several (3.5) 1 (2.A couple of) One particular (0.Only two) One (2.Two) ????GI ulcer Zero 3 0 3 One (Zero.Two) Zero Zero 6 (One particular.0) Several (1.Only two) One (Zero.Two) 4 (2.Seven) Three or more (2.Five) ????Abdominal distension 0 2 Zero Zero 2 A single (Zero.Two) 0 15 (Two.Three or more) 1 (Zero.2) Zero 2 (0.Several) Zero ????Dyspepsia Zero 0 2 2 Your five (Zero.7) 3 3 12 (2.Zero) 3 3 4 (Zero.7) 3 ????Gastritis 0 Zero 3 0 0 One particular (Zero.A couple of) 2 Several (2.Five) One (Zero.2) Zero Zero A single (2.A couple of) ????Duodenitis 2 0 Zero 0 3 2 2 3 One (2.Only two) 0 One (2.Two) 0 ????Intestinal impediment 0 0 2 Zero A single (Zero.Two) One particular (Zero.A couple of) 2 3 Three or more (Zero.A few) 1 (0.Only two) 1 (2.Only two) 0 ????Constipation 3 0 2 2 11 (1.8-10) 0 2 (Zero.3) 7 (One particular.Three or more) 3 0 Zero 2 ????Diarrhea 3 Zero 2 2 Your five (3.8) 3 Zero Several (Zero.7) 3 3 Zero 3 ????Flatulence 3 2 (0.Three or more) 0 2 A single (0.2) Zero 3 Four (3.Seven) 3 Zero 3 3 Constitutional 3 [http://www.selleckchem.com/products/a-1155463.html A-1155463 cost] 32 (Your five.Three) 5 (0.Eight) Three (2.Your five) 114 (18.Eight) Seven (One.Only two) Some (One.Zero) 162 (26.7) Twenty-five (Several.One) 4 (0.7) 30 (4.One particular) Some (1.Zero) ????Fatigue 3 31 (4.6) 4 (3.Seven) 3 Ninety six (Fifteen.8) Some (One.0) Some (0.Seven) 154 (25.4) 25 (Three or more.Six) A couple of (3.Three) 21 years old (Three.A few) 4 (Zero.7) ????Fever 0 Three or more (Zero.5) A single (Zero.A couple of) A couple of (2.Three or more) 28 (4.Half a dozen) 2 One particular (0.Only two) Eighteen (Several.Zero) One (3.2) 3 Two (Zero.Three) Zero ????Weight reduction 0 3 0 2 1 (3.Two) Zero One (0.A couple of) Six (One particular.2) Zero 0 Several (Zero.Seven) 2 ????Peripheral hydropsy Zero Zero 0 3 Zero 3 [http://www.selleckchem.com/products/cb-5083.html this website] 1 (Zero.2) One (0.2) A couple of (Zero.Three) 2 (2.Several) Only two (Zero.Three or more) Only two (3.3) Psychiatric Zero Only two (3.3) Zero 1 (3.2) Eighteen (Three or more.0) 3 (3.Five) Several (2.A few) Twenty-six (Four.Three) Three (0.Five) Zero Several (2.A few) 2 ????Anorexia nervosa Zero 2 (3.Several) 2 One particular (Zero.A couple of) 19 (2.Eight) Several (Zero.5) Several (0.5) Twenty-six (Four.Several) Three (Zero.Your five) Zero Several (2.Your five) 3 Hepatobiliary Zero 2 0 0 Your five (0.8-10) 3 0 Forty three (7.A single) Thirty five (5.8) A couple of (0.3) Thirty-one (5.One particular) 25 (Three or more.Some) ????Hyperbilirubinemia 0 Zero 2 3 One (2.A couple of) 3 3 36 (Your five.Nine) 20 (Three.0) One particular (3.Two) 40 (Your five.0) 18 (Three or more.0) ????Ascites 2 2 0 0 Zero 3 One (3.Two) In search of (One.Your five) 12 (One particular.8) One particular (Zero.2) 3 (Zero.Five) Half a dozen (One particular.0) ????REILD Zero Zero Zero 3 3 Zero Five (0.8) A couple of (2.Three) 3 (0.5) One particular (0.Only two) One particular (0.Two) 3 ????Cholecystitis 3 0 0 0 Only two (Zero.Three or more) 2 Zero 3 (3.Five) 1 (3.2) Zero 1 (0.Only two) One particular (Zero.A couple of) ????Hepatic malfunction Zero 2 Zero 2 1 (Zero.2) 0 3 Two (0.Several) Two (2.Several) A couple of (3.3) 0 2 Soft tissue 3 2 (3.Three) A single (Zero.Two) 3 7 (One particular.Two) Zero One (Zero.Two) 8 (One particular.3) 2 0 Only two (Zero.Three) Zero ????Back pain 2 Zero 3 2 Five (0.8-10) Zero Zero A single (2.Two) Zero 0 Only two (Zero.Three or more) 0 Vascular disorders Zero 1 (0.A couple of) Zero Zero 3 (2.A few) Three or more (Zero.Your five) One particular (3.2) 4 (Zero.6) Three or more (0.Five) 1 (3.2) Zero One particular (0.2) 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