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The aim of this study was to investigate whether GAD-alum treatment affected the GADA epitope pattern. Methods: Serum samples from patients treated with GAD-alum (n = 33) or placebo (n = 27), at baseline, 1, 3, 9, and 15 months after the initial injection, were tested for their binding capacity to specific GADA epitopes in an epitope-specific radioligand binding assay with six recombinant Fab (rFab) (b96.11, DPA, DPD, MICA3, b78, and N-GAD65 mAb). Results: No significant differences in variability of binding to any of the tested rFab were observed from baseline to 15 months. There was a sustained low binding of [http://www.selleckchem.com/products/Y-27632.html selleck] GADA to the b78- and N-GAD65 mAb-defined epitopes, often recognized by GADA in patients with stiff person syndrome (SPS) and seldom in T1D patients. However, binding of GADA to the T1D-associated b96.11-defined epitope increased between baseline and 3 months in GAD-alum (?8.1%, min ?72.4%, max 39.6%) compared to placebo patients (1.5%, min ?28.3%, [http://www.selleckchem.com/products/AZD2281(Olaparib).html Olaparib ic50] max 28.6%) (p = 0.02). Subsequently, the b96.11-defined epitope recognition returned to levels similar to that observed at baseline. Conclusions: GAD-alum injections did not affect binding of GADA to SPS-related epitopes, further supporting the safety of the treatment. There were no changes in GADA epitope specificity to the T1D-related epitopes, except for a temporarily increased binding to one of the tested epitopes. ""The calculation of prandial insulin dose is a complex process in which many factors should be considered. High glucose variability during the day, arising from difficulties which include errors made in food counting and inappropriate insulin adjustments, influence hemoglobin A1c levels. During this study, in children using insulin pumps to manage type 1 diabetes, we compared 2-h postprandial blood glucose levels (BGL) and glucose variability when calorie tables and mental calculation were used, to when Diabetics software was used. This 3-month, randomized, open-label study involved 48 children aged 1�C18 yr. Patients were educated in food counting system used in the Warsaw Pump Therapy School (WPTS) where the carbohydrate [https://en.wikipedia.org/wiki/Bepotastine bepotastine] unit (CU) and the fat�Cprotein unit (FPU) are taken into account. The children were randomly allocated to an experimental group (A) who used Diabetics software and a control group (B) who used caloric tables and mental calculations. We observed significant differences (p