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1%) were premenopausal and 353 of them were without CIA, 492 patients were postmenopausal. As shown in Table 1, a total of 353 patients with a median age (at disease onset) of 41 years (range, 24 to 50 years) were recruited. Of these patients, 69 (19.5%) received neoadjuvant chemotherapy with regimens containing anthracycline and/or taxanes and the median number of cycles of chemotherapy was 2 (range, 2 to 6 cycles). All patients received adjuvant [http://www.selleckchem.com/screening/pi3k-signaling-inhibitor-library.html PI3K Inhibitor Library solubility dmso] chemotherapy, and 343 patients received regimens with anthracycline and/or taxanes and 10 patients received regimens containing cyclophosphamide, methotrexate, and 5-fluorouracil (CMF). The median number of cycles of adjuvant chemotherapy was 4 (range, 2 to 6 cycles). Table 1. Clinicopathologic characteristics of patient groups For patients without neoadjuvant chemotherapy, the median number of cycles of adjuvant chemotherapy was 6 (range, 4 to 8 cycles). Adjuvant radiotherapy was mainly delivered to the ipsilateral chest wall, supraclavicular and infraclavicular region after mastectomy. The total radiation dose was 50 Gy with 2 Gy delivered over 25 times. However, no patient received herceptin. After adjuvant radiotherapy, endocrine [http://www.selleckchem.com/products/Sunitinib-Malate-(Sutent).html check details] therapy was initiated. Of these patients, 255 patients (72.2%) were treated with tamoxifen (TAM) without ovarian suppression; 98 (27.8%) were treated with TAM and goserelin once monthly for a median duration of 31 months (range, 24 to 59 months), 83/98 patients (84.7%) were treated based on resumption or persistence of menstruation, and 15/98 patients (15.3%) were treated based on hormone levels. After completion of goserelin treatment, 68 patients (69.4%) recovered their menstrual cycle within one year and the remaining 30 patients developed amenorrhea (30.6%). 2. Survival The median follow-up period was 61 months (range, 12 to 144 months). Locoregional recurrence was observed in 16 patients. The 5- and 10-year LRFS were 95.8% and 94.1%, respectively. Distant metastasis was noted in 90 patients, and the 5- and 10-year DMFS were 75.6% and 62.3%, respectively. The 5- and 10-year DFS [https://en.wikipedia.org/wiki/Fossariinae Fossariinae] were 75.4% and 59.4%, respectively. In addition, 61 patients died of breast cancer, and the 5- and 10-year OS were 86.1% and 63.1%, respectively. 3. Influence of goserelin on survival Results of univariate analysis are shown in Table 2. Treatment with goserelin (when compared with goserelinuntreated patients) resulted in significantly improved LRFS (98.9% vs. 94.1%, p=0.041), DMFS (85.4% vs. 71.9%, p=0.006), DFS (85.4% vs. 71.6%, p=0.005), and OS (93.5% vs. 83.5%, p=0.010) (Figs. 1-?-4).4). In addition, molecular subtypes, pN stage, and neoadjuvant chemotherapy also influenced breast cancer prognosis (p