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Contrary, Indigenous patients have a higher proportion diagnosed in regional/advanced stage resulting in a potential higher risk for development of metastatic disease. Indigenous patients indeed have innately different tumour characteristics from non-Indigenous. A. Lomax1, H. Wong2, K. Field3, M. Harold4, J. Shapiro5, J. McKendrick1, A. Zimet6, D. Yip7, L. Nott8, R. Jennens6, G. Richardson5, J. Tie2,3,9, S. Kosmider9, P. Parente1,10, L. Lim1, P. Cooray1, B. Tran2,3,9, J. Desai2,3, R. Wong1, P. Gibbs2�C4,9 1Department of Medical Oncology, Eastern Health, Melbourne, Australia, 2Walter and Eliza Hall Institute of Medical Research, Melbourne, [http://www.selleckchem.com/products/sch772984.html click here] Australia, 3Royal Melbourne Hospital, Melbourne, Australia, 4BioGrid Australia, Melbourne, Australia, 5Cabrini Health, Melbourne, Australia, 6Epworth Richmond Hospital, Melbourne, Australia, 7Canberra and Calvary Hospitals and ANU Medical School, Canberra, Australia, 8Royal Hobart Hospital, Hobart, Australia, 9Western Hospital, Melbourne, Australia, 10Monash University, Faculty of Medicine, Nursing and Health Sciences, Eastern Health Clinical School, Box Hill, Australia Background:?Variation in outcomes for rectal (RC) and colon (CC) cancer have been reported, particularly in the advanced disease setting. Established differences in patterns of metastatic spread and recently described molecular analyses suggest differences in clinicopathological [http://en.wikipedia.org/wiki/Ritonavir Ritonavir] features that may impact on prognosis. Here we aim to compare presenting features and outcomes in metastatic RC versus CC. Methods:?Analysis of patients with newly diagnosed metastatic colorectal cancer enrolled onto an Australian prospective multi-centre registry. Disease characteristics, treatment and overall survival were compared for patients with RC versus CC using the chi-square and Cox proportional hazards methods. Results:?Of 1048 patients, 305 (29%) had RC and 730 (70%) CC. Patients with RC were younger (median age 65 versus 70 years, p?[http://www.selleckchem.com/products/dabrafenib-gsk2118436.html Dabrafenib cell line] and peritoneal (22 versus 6%, p?