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In view of the suggested osteopromotive capacity of bioactive glasses (BGs), this study aimed to evaluate the effect of BG incorporation into HA coatings on implant performance in terms of bone contact and bone area. A total of 48 screw-type titanium implants with magnetron sputter coatings containing different ratios of HA and BG (HA, HABGLow, and HABGHigh; n?=?8) were placed into the mandible of 16 Beagle dogs. After 4 and 12?weeks, their performance was evaluated histologically and histomorphometrically. Peri-implant bone area percentage (BA%) was determined in three zones (inner, 0�C500?��m; middle, 500�C1000?��m; and outer, 1000�C1500?��m). Additionally, bone-to-implant contact [http://en.wikipedia.org/wiki/Isotretinoin Isotretinoin] (BIC%) and first bone�Cimplant contact (1st BIC) were assessed for each sample. After 4?weeks, bone-to-implant contact for the HA- and HABGLow-coated groups was significantly higher (P?[http://www.selleckchem.com/products/incb28060.html INCB28060 in vivo] and HABGHigh (56.3%)-coated groups. Data suggest that the relative BA around the HA-coated implants (67.8%) was higher, although this was only significant compared to the HABGHigh group. After 12?weeks, all three groups showed similar bone-to-implant contact and no differences in BA were found. The incorporation of BG into HA sputter coatings did not enhance the performance of a dental implant in implantations sites with good bone quality and quantity. On the contrary, coatings containing high concentrations of BG resulted in inferior performance during the early postimplantation healing phase. Oral implants, generally made of pure titanium or titanium-based alloys, are widely used in the prosthetic rehabilitation of fully and partially edentulous patients. Furthermore, multiple long-term [http://www.selleckchem.com/products/gdc-0068.html learn more] clinical studies on implant survival report on high clinical survival rates reaching up to 100% after 5?years in function (Tinsley et?al. 2001). The ultimate goal in implant therapy is to achieve an early and strong implant fixation into the native surrounding bone tissue. Although titanium is commonly used as a favorable bone implant material due to its mechanical properties, its bioactive and osteoconductive capacity is relatively low (Le Gu��hennec et?al. 2007). Therefore, implant surface modification experiments intend to improve the early process of osseointegration, as characterized by an increased bone-to-implant contact and enhanced bone volume in the area surrounding the implant (Fontana et?al. 2011). For this purpose, different surface modification approaches have been explored to optimize the interaction between implants and native bone tissue. By altering either surface topography (i.e., grit blasting and acid etching) or changing the physicochemical properties of the surface (i.e.