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Similarly, depletion of CD25 cells and TGF-�� neutralization but not of IL-10 neutralization [http://en.wikipedia.org/wiki/Ritonavir Ritonavir] lead to an increase in PE-specific antibody levels and elevated mast cell degranulation following a PE challenge. Conclusions and Clinical Relevance We conclude that CD4+CD25+ Tregs from non-transgenic-tolerant mice cannot transfer specific oral tolerance of exogenous antigens to na?ve mice and are more involved in general immune suppressive mechanisms. However, we found evidence that TGF-�� secreting Tregs (Th3) may play an important role. Cite this as: M. Marcondes Rezende, I. Hassing, M. Bol-Schoenmakers, R. Bleumink, L. Boon, J. van Bilsen and R. Pieters, Clinical & Experimental Allergy, 2011 (41) 1324�C1333. ""To cite this article: Hommel KA, Franciosi JP, Gray WN, Hente EA, Ahrens A, Rothenberg ME. Behavioral functioning and treatment adherence in pediatric eosinophilic gastrointestinal disorders. Pediatr Allergy Immunol 2012: 23: 494�C499. Objective:? To examine behavioral predictors of treatment adherence in patients with eosinophilic gastrointestinal disorders (EGID). Methods:? Participants were 96 patients 2.5�C18?yr of age with eosinophilic esophagitis or eosinophilic gastroenteritis and their caregivers (mother, father). We assessed maternal and paternal report of child/adolescent internalizing symptoms (e.g., anxiety, depression) and externalizing symptoms (e.g., aggression, anger) using the Behavior Assessment System for Children, 2nd edition (BASC-2). A multi-informant adherence assessment approach and an [http://www.selleckchem.com/products/dabrafenib-gsk2118436.html Dabrafenib in vitro] 80% cut point were used to classify patients as adherent or non-adherent. Results:? Sociodemographic predictors did not distinguish between adherent and non-adherent patients. Maternal report of internalizing symptoms [http://www.selleckchem.com/products/sch772984.html SCH772984] significantly correlated with non-adherence (p?