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The regression results confirm that four of these primary variables were statistically significant in the final model: 1) arriving on weekends or holidays (=0.186, p[https://en.wikipedia.org/wiki/Pentamorphone Pentamorphone] and 2) arriving during after-hours (=0.253, p[http://www.selleckchem.com/products/LBH-589.html selleck compound] the period 8am �C 5pm compared to the period 5pm �C 8am. Figure 2 Distribution of STEMI patients by time of day. Mortality rates were also significantly different in the logistic regression for those patients arriving during after hours (OR 2.23, p[http://www.selleckchem.com/products/Adriamycin.html Adriamycin datasheet] on non-holiday weekdays than on weekends or holidays. Second, patients who arrived 8am �C 5pm had a median D2B time that was 16 minutes shorter than for those who arrived 5pm �C 8am. The 2.23 OR for mortality for patients presenting after hours vs. during business hours is relatively high, compared to the 16-minute difference in median D2B times (75 minutes vs. 59 minutes). This appears to be a disproportionately elevated mortality rate. This also contrasts significantly with the 1.06 OR for mortality for after-hour STEMI presentations in the systematic review and meta-analysis by Sorita et al.,16 which demonstrated a similar D2B time delay (14.8 minutes) for after-hour SETMI presentations.