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Measurement of total serum immunoglobulin E (IgE) has limited use in the general population due to a low negative predictive value. The value of total IgE level in select populations [http://www.selleckchem.com/products/ABT-888.html selleck] undergoing in vitro allergy testing remains unknown. The aim of this study is to determine the utility of total serum IgE in the in vitro diagnosis of allergic rhinitis. A retrospective chart review of patients undergoing testing for allergic rhinitis was performed. Clinical parameters, total IgE level, and enzyme-linked immunosorbent assay (ELISA) for serum-specific IgE levels were analyzed with multivariate logistic regression. The positive and negative predictive values and a receiver operating characteristic (ROC) curve were used to assess the utility of total IgE in predicting serum-specific IgE test results. Records from 1073 patients were reviewed. ROC curve for total IgE >150 IU/mL (�� 0.88) indicates good discrimination in identifying patients with sensitization by in vitro testing, whereas low total IgE level had strong negative predictive value (0.87, IgE [https://en.wikipedia.org/wiki/Lazabemide lazabemide] patients with low serum total IgE, whereas high total IgE level suggests that in vitro testing would confirm specific sensitizations in patients with allergic rhinitis. Allergic rhinitis (AR) is a common inflammatory disease that is defined [http://www.selleckchem.com/products/DAPT-GSI-IX.html this website] by an immunoglobulin E (IgE)-mediated triggering of nasal congestion, rhinorrhea, sneezing, and itching in response to specific environmental triggers. AR affects 10% to 30% of Americans and up to 40% of children.[1] The gold standard for diagnosis of AR is a clinical summary of history, physical exam findings, and measurement of specific IgE reactivity. A challenge remains in correctly identifying AR in the absence of absolute objective measures and limitations in current testing strategies. Symptoms of AR cause a significant impact on quality of life; AR is associated with loss of productivity and a financial expenditure ranging in the billions of dollars every year through direct and indirect medical costs.[2] The expense of allergy testing is affected by the method of testing and number of tests performed. There are multiple allergy testing methods that have individual advantages and disadvantages. One simple test that has been viewed as a potential cost-saving measure is the use of total serum immunoglobulin E (tIgE) levels to rule out or assist in identifying sensitization to specific allergens.