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Forty women with DO and OAB together with anterior wall prolapse who underwent a repair between 2003 and 2007 were studied. Each woman was assessed pre- and post-operatively with a clinical assessment and cystometry. Opening pressures were recorded pre- and post-operatively for each patient by retrospective review of the pressure flow traces. Patients were divided into those who experienced resolution of OAB symptoms and those with persistent OAB symptoms. Wilcoxon matched pairs signed rank test was used to assess any change in opening pressures between these groups. Resolution of urgency with an anterior repair was associated with a significant fall in ODP from a mean of 27.9 to 11.7?cmH2O (P?=?0.01). [http://en.wikipedia.org/wiki/GUCY1B3 GUCY1B3] There was no significant pre-operative difference in ODP between women in whom urgency resolved and those in whom it did not. These results suggest that a fall in ODP is associated [http://www.selleckchem.com/products/Gefitinib.html Gefitinib supplier] with resolution of urgency in women undergoing prolapse surgery. This may imply that decreased urethral resistance is of importance in symptom resolution. 30:595�C598, 2011. ? 2011 Wiley-Liss, Inc. ""Beta3-adrenoceptor selective agonists are evaluated as a new treatment for patients with lower urinary tract symptoms . It is believed that ��3-AR selective agonists exert their effects via a peripheral site of action. However, ��3-ARs have been found in brain tissue. This study examined whether ��3-ARs are present in rat sacral spinal cord, and whether there are differences in ��3-AR expression between normal and partial urethral obstruction (PUO) animals, and furthermore assessed the functional relevance of spinal ��3-ARs for micturition. Thirty-eight male Sprague�CDawley rats underwent either PUO or sham-operation. Two weeks after operation, half of the animals were used for histomorphological analysis. Remaining animals were used for functional experiments, where a ��3-AR selective agonist, BRL 37344, was given intrathecally. Bladder function was assessed by continuous cystometry in non-anesthetized animals before and after drug administration. Beta3-ARs were found in sacral spinal [http://www.selleckchem.com/products/LBH-589.html Panobinostat] cord segments with an accumulation in the ventral horn. There was a significant increase of ��3-AR expression in obstructed rats. In functional experiments obstructed rats showed increased bladder weight, micturition frequency, spontaneous activity, and bladder pressures (all P?