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05) associated with the prevalence of ischemic stroke (Table [https://en.wikipedia.org/wiki/Sclareol Sclareol] II). The genotype distributions and allele frequencies of rs2075650 of the translocase of outer mitochondrial membrane 40 homolog (TOMM40) gene and of rs273909 of the solute carrier family 22, member 4 (SLC22A4) gene were significantly associated with the prevalence of ischemic stroke. Allele frequencies of rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1) were also significantly associated with ischemic stroke. These SNPs were further examined by multivariable logistic regression analysis with adjustment for covariates. Table II. Comparisons of genotype distributions and allele frequencies of rs9319428 of FLT1, rs2075650 of TOMM40 or rs273909 of SLC22A4 by the ��2 test between subjects with ischemic stroke and controls. Multivariable logistic regression analysis The multivariable logistic regression analysis was performed with adjustment for age, gender, BMI, smoking status and the prevalence of hypertension, diabetes mellitus and dyslipidemia [http://www.selleckchem.com/products/PLX-4032.html Vemurafenib] and revealed that rs2075650 of TOMM40 (recessive and additive 2 models) and rs273909 of SLC22A4 (dominant and additive 1 models), but not rs9319428 of FLT1, were significantly (P or CKD was examined in all the subjects (Table IV). The rs2075650 of TOMM40 or rs273909 of SLC22A4 was significantly (P[http://www.selleckchem.com/products/AZD2281(Olaparib).html buy Olaparib] associations of rs2075650 of TOMM40 or rs273909 of SLC22A4 were examined with the clinical parameters including systolic, diastolic and mean blood pressure, pulse pressure, serum concentrations of triglycerides, LDL-cholesterol, HDL-cholesterol, creatinine, fasting plasma glucose level and eGFR (Table V). To avoid the effects of medical treatment on clinical parameters, the corresponding controls were examined for hypertension, dyslipidemia, diabetes mellitus or CKD. The rs2075650 of TOMM40 was not associated with any clinical parameter, whereas rs273909 of SLC22A4 was associated with fasting plasma glucose level (recessive model). Table V.