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0. Armonk, NY: IBM Corp. (SPSS Inc., 2010)/STATA by comparing study and control groups at baseline and each follow-up on the assessments used. Generalized estimation equation (GEE), which is an advanced statistical method for analyzing longitudinal data and better than conventional repeated measures[11] (RMANOVA) was used to assess within group change with time and overall difference between the groups to see any paired changes between baseline, 3 and 6 months follow-up. The significance criterion was set to P [http://www.selleckchem.com/products/epacadostat-incb024360.html Epacadostat in vivo] that completed the SKY program as compared to those who did not were observed. The domain scores of the two groups over time are given in Table 2. The GEE model results showed that between the two groups over time (study vs. control) the scores of physical (P [http://en.wikipedia.org/wiki/ATPase ATPase] higher in the study group indicating a better QOL. Within the group, changes were compared for baseline as compared to 3 months follow-up and 6 months follow-up separately. For study group, compared to baseline, no differences in Physical domain scores at 3 months follow-up were observed, the scores however increased significantly at 6 months follow-up (P [http://www.selleckchem.com/products/MG132.html Selleckchem MG-132] and 6 months follow-up (P  physical, psychological and environment domain scores over time were observed except for social relationships domain, which was significantly higher at 6 months [Table 2]. No statistical differences in urine screening results between study and control group were observed at baseline (Fisher exact test, P = 0.226) and 3 months follow-up (P = 0.287). At 6 months follow-up, all users in the study group had negative urine test results (P