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FEF25�C75 increased from a mean of 50.75% to 68.85% predicted (P?[http://www.selleckchem.com/products/i-bet151-gsk1210151a.html GSK1210151A price] plethysmographic [http://en.wikipedia.org/wiki/RhoC RhoC] measurements of specific airway conductance (sGaw), and to investigate whether changes in functional residual capacity (FRC) occur during methacholine-induced bronchoconstriction in infants. We examined 94 infants with recurrent airway symptoms using methacholine airway challenge test including RTC and plethysmographic measurements. A significant association between changes in V'maxFRC and sGaw (r?=?0.30; P?=?0.004) was observed, but after adjustments with baseline variability the changes in V'maxFRC were greater and showed a closer association with changes in oxygen saturation. At the point of maximal airway obstruction, there was a poor agreement between V'maxFRC and sGaw to indicate a significant methacholine-induced bronchoconstriction. Airway challenge was also associated with a significant increase in FRC (P?[http://www.selleckchem.com/products/epacadostat-incb024360.html INCB024360 order] airway challenge with methacholine, plethysmographic measurements of sGaw correlate with the changes in VmaxFRC, but the agreement is poor and the methods cannot be used interchangeably. VmaxFRC is also more sensitive to detect airway obstruction than sGaw. However, methacholine-induced bronchoconstriction was associated with significant increases in FRC, which may affect the validity of VmaxFRC measurements during the test. Pediatr Pulmonol. 2011; 46:362�C368. ? 2010 Wiley-Liss, Inc. ""This study investigated environmental endotoxin exposure during early life, sensitization to aeroallergens, the production of cytokines by LPS-stimulated leukocytes, and the development of a wheezing phenotype in a prospective cohort of infants with high risk of developing allergic diseases. Eighty-four infants were followed from birth until 30 months of age. We assessed endotoxin concentration in house dust of their homes during the first 6 months of life.