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Patients were administered the EQ-5D questionnaire at discharge from the index hospitalization, at the 6-month visit, and at the end-of-treatment (EOT) visit, which was anticipated to be at 12 months. As previously described, the PLATO trial was an event-driven study. The primary efficacy end point was death from vascular causes, myocardial infarction, or stroke. As part of the trial, outpatient visits were scheduled at 1, 3, 6, 9, and 12 months, with a safety follow-up visit 1 month after the EOT. The randomized treatment was scheduled to continue for 12 months, but patients left the study at their 6- or 9-month visit if the targeted number of 1780 primary end-point events had occurred by that time. The primary end point for the HRQOL substudy was the EQ-5D questionnaire single index utility score at 12 months after enrollment. For patients who [http://www.selleckchem.com/products/Sunitinib-Malate-(Sutent).html check details] had [http://www.selleckchem.com/products/3-methyladenine.html 3-Methyladenine solubility dmso] EOT assessments at 6 or 9 months as a result of the trial reaching the requisite number of end points, the EQ-5D questionnaire value at the EOT assessment was assumed to be equivalent to that at the 12-month assessment. For patients with early EOT assessments for reasons other than completion of the trial, or with EQ-5D questionnaire assessment only at discharge from the index hospitalization, the last available EQ-5D questionnaire assessment was applied on the basis of the last value carried forward (LVCF) principle [12]. Patients who died prior to the EOT visit were assigned an end-point value of 0. And finally, patients who rated their health state worse than death (negative EQ-5D questionnaire) were reassigned a value of 0. The mean end-point EQ-5D questionnaire single index for patients assigned to ticagrelor and clopidogrel was compared by using a Student��s t test. Treatment comparisons were based on intention-to-treat. The result was confirmed by using a nonparametric bootstrap analysis with 10,000 bootstrap replicates. A multiple linear regression model was used to study the association between treatment, demographic and clinical factors, and the end-point EQ-5D questionnaire [https://en.wikipedia.org/wiki/Ceftiofur Ceftiofur] single index. Variables included in the model were treatment (ticagrelor vs. clopidogrel), age (divided into three classes,��49 years, 50�C74 years [reference class], and��75 years), sex, and body mass index (divided into three classes,