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Their serum albumin, glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine levels as well as fructosamine levels were measured using an modular EVO automated chemistry analyzer (Roche, Basle, Switzerland). The subjects' HbA1c levels were measured with Bio-Rad Variant II TURBO (Bio-Rad Laboratories, Tokyo, Japan) via high-performance liquid chromatography (HPLC). Their hemoglobin levels were determined through the cyanide-free sodium lauryl sulphate (SLS) method using the Sysmex XE-5000 automated hematology system (Sysmex Corp., Kobe, Japan). Their total T3, free T4, and TSH concentrations were analyzed in a Cobas 6000 (Roche, Tokyo, Japan) autoanalyzer according to the results of an electrochemiluminescence [http://en.wikipedia.org/wiki/Diglyceride diglyceride] immunological test (ECLIA). The levels of serum fructosamine and plasma HbA1c, as well as of blood glucose, were reviewed based on clinical information. [http://www.selleckchem.com/products/a-1210477.html selleck] The correlation among plasma HbA1c, serum fructosamine, and estimated fructosamine levels was investigated, and they were compared with the average glucose level estimated via HbA1c and that estimated via fructosamine. 3. Statistics All the data were expressed as mean��standard deviaton values. All the statistical analyses were performed using IBM SPSS Statistics ver. 21 (IBM Co., Armonk, NY, USA). Independent samples t-test was used to compare the clinical and biochemical parameters between the T1DM and T2DM groups. To evaluate the relationship between HbA1c and fructosamine, a linear regression analysis was used. A P value of [http://www.selleckchem.com/products/ldn193189.html LDN-193189 supplier] Review Board of Dankook University Hospital (IRB No. 2014-07-015). Informed consent was waived by the IRB. Results Among 74 patients, 37 were male and 37 were female. A total of 245 samples were assayed for HbA1c and fructosamine. Their mean��standard deviation values were 9.05%��2.56% and 393.53��143.49 ?mol/L, respectively. The mean age at the time of diagnosis and assay, and the duration of the disease at assay, were 9.87, 12.94, and 3.31 years, respectively (Table 1). The HbA1c levels showed strong correlations with the fructosamine levels (r=0.868, P