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75 mg weekly, 1.5 mg weekly and basal insulin (titrated to fasting glucose levels). At the end of 1 year, the mean reductions in HbA1c were 0.76, 1.08, and 0.63% in dulaglutide 0.75 mg, 1.5 mg, and glargine groups, respectively (p  albiglutide and glargine, HbA1c decreased from 8.28 �� 0.90% (67.0 �� 9.8 mmol/mol) (mean �� SD) at baseline to 7.62 �� 1.12% (59.8 �� 12.2 mmol/mol) at week 52 in the albiglutide [http://www.selleckchem.com/products/SB-431542.html SB431542 datasheet] group with a similar reduction in the glargine group (from 8.36 �� 0.95% to 7.55 �� 1.04%) [Pratley et al. 2013]. Body weight increased in the glargine group and decreased in the albiglutide group, with a mean treatment difference of �C2.61 kg (95% CI �C3.20, �C2.02; p  with biphasic insulin aspart (HbA1c change: exenatide �C1.04% �� 0.07%, biphasic insulin [http://en.wikipedia.org/wiki/Megestrol_acetate Megestrol Acetate] aspart �C0.89% �� 0.06%; difference �C0.15%; 95% CI �C0.32% to 0.01%). Exenatide-treated patients lost weight, while patients treated with biphasic insulin aspart gained weight (between-group difference �C5.4 kg; 95% CI �C5.9 [http://www.selleckchem.com/products/INCB18424.html JAK inhibitor] to �C5.0 kg). Both treatments reduced FPG (exenatide �C1.8 �� 0.2 mmol/liter, p