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A union was defined as healing on at least three cortices on two views without bony tenderness on palpation, noted in the chart. Weight-bearing status at 1-year minimum follow-up was also noted. Statistical analysis was performed via Statistical Package for the Social Sciences (SPSS) version 18.0 (IBM Corp., Somers, NY, USA). Mean values for alignment were calculated denoting valgus as a positive number and varus as a negative number, in the frontal plane, and procurvatum as a positive number and recurvatum as a negative number, in the sagittal plane. A continuous variable comparison was performed via unpaired Student's t-test. Significance was set at p?[http://www.selleckchem.com/products/Methazolastone.html Temozolomide nmr] sustained their injuries as a result of a fall (57%). The majority of our patients sustained AO/OTA type 43C1 fractures (70%). Only six fractures (26%) were open; classified by Gustilo and Anderson open fracture criteria, three grade 2, two grade 3As and one grade 3B types were noted.23 Sixteen (58%) had an associated fibular fracture, while three (13%) were categorised under polytrauma, as having more than two concomitant fractures, while four patients (17%) had isolated fractures of interest. Only one [http://www.selleckchem.com/products/GDC-0449.html learn more] patient reported a history of diabetes, while five reported a smoking history (Table 1). Twenty (87%) patients received additional non-IM distal screws, with the cohort receiving an average of two-and-a-half screws with a total of 58 screws. Two surgical techniques were used: 13 (57%) patients received nails in the semi-extended position, while 10 (43%) patients received medial parapatellar nails in the supine position (Table 2).21 Besides the 7 patients lost to follow-up, all 23 patients (100%) achieved bony union at a mean time of 14.1?��?4.9 weeks with a full-weight-bearing status. No malalignments were seen in any plane either in the immediate postoperative period or at the time of union. Mean alignment in the frontal plane did not significantly change, [https://en.wikipedia.org/wiki/Moroxydine Moroxydine] remaining in slight valgus (valgus denoted by ��+��, varus denoted by ��?��) from the immediate postoperative period to the time of union (+1.3?��?1.7�� vs. +1.3?��?1.7��, p?=?0.93), exhibiting a mean alignment change of +0.044?��?059��. Mean alignment in the sagittal plane did not significantly change from the immediate postoperative period to the time of union, moving from recurvatum (procurvatum denoted by ��+��; recurvatum denoted by ��?��) to slight procurvatum (?1.3?��?2.5�� to ?1.2?��?2.4��, p?=?0.89), exhibiting a mean alignment change of +0.10?��?0.86�� ( Table 3). Complications were minimal. One patient exhibited non-union of the tibial shaft component of the fracture, required bone grafting and subsequently went on to union at 28 weeks.