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We set the significance value at p?[http://en.wikipedia.org/wiki/Oxalosuccinic_acid Oxalosuccinic acid] level was 1.7 (IQR 1.1�C4.5) and the median creatinine level was 0.40?mg/dL (0.2�C0.7). The mortality risk according to the PRISM score was 7.6%, and 1.3% according to the PELOD score. Spontaneous circulation returned in 40 (90%) patients and 26 (59.1%) survived to hospital discharge. We could not perform a statistical [http://www.selleck.co.jp/products/Romidepsin-FK228.html find more] analysis to study the relationship with ROSC because only 4 patients failed to recover spontaneous circulation. Table 2 compares the parameters of the deceased patients and the survivors in relation to pre-arrest severity of illness and treatments. There were no differences in the PRISM and PELOD paediatric severity of illness scores, in the adult CA prognostic score, nor in the creatinine levels of survivors vs. non-survivors. There was no difference in mortality associated with treatment with inotropic drugs (58.6% of patients who received inotropic drugs survived, as did 64.3% of patients who did not). Patients who were given adrenaline had a lower survival rate (52.4%) than patients who did not receive it (65.2%), although the difference was not statistically significant. There were no statistically significant differences in association with the number of inotropic drugs given to the patients, although none of those who were given 4 or [http://www.selleck.co.jp/products/Adrucil(Fluorouracil).html 5-FU research buy] more inotropic drugs survived CA. Pre-resuscitation lactate levels in non-survivors were significantly higher than in survivors. Table 3 summarises the relative risk of mortality of pre-arrest lactate values greater than 1.5?mmol/L and 4?mmol/L. The area under the ROC curve was 0.69 (confidence interval 0.51�C0.87), p?=?0.05. The 4?mmol/L cut-off point classified 66.7% of the patients accurately. Several studies have analysed the relationship between patient characteristics (age, sex) and underlying diseases, the general and neurological performance status, and the causes of CA and CPR characteristics with prognosis after CA in adults and children.1, 2, 3, 4, 5, 6, 7, 8?and?9 However, few have studied the relationship between the previous health status of the patient and prognosis. Our study is the first to analyse the relationship between severity of illness and prognosis after in-PICU CA. The PRISM and PELOD1, 2, 3, 4, 5, 6, 7, 8?and?9 scores are validated prognostic indicators for children admitted to intensive care units.