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Serum samples were collected for total and specific IgE measurements. [http://www.selleckchem.com/products/AZD8055.html Selleck AZD8055] Clinical data were obtained by questionnaires. Results:? Sensitization rates to birch pollen increased from 7.8% to 14.8% (P?[http://en.wikipedia.org/wiki/Diglyceride diglyceride] and case definition (1, 2). The former focused on schoolchildren and the latter on adults. Time-trend analyses [http://www.selleckchem.com/products/S31-201.html S3I-201 chemical structure] of the ECRHS data showed that asthma incidence has progressively increased by years of birth in European adults born between 1946 and 1971; each new generation had more incident asthma than the previous (2). The emerging picture based on the ISAAC data is that although the global burden of asthma and allergic rhinitis is continuing to rise, the global differences in prevalence are shrinking. In many English-speaking countries, the rising trends in occurrence of allergic diseases appear to have levelled off, or even reversed, while in many developing countries, the increase in prevalence has only recently started (1, 3). Thus far, no definite and overarching explanation has been given either for the rise or particularly for the decline in prevalence (4). In an earlier generational analysis of schoolchildren and their mothers, we found that in Russian Karelia, an economically depressed area next to the Finnish eastern border, the younger generation was no more allergic than the older; rather, the opposite was true. In Finland, by contrast, a substantial increase in the prevalence of atopy and atopic disease in children emerged when compared to their mothers. Based on these results, there had been no signs of westernisation, using atopy as a proxy, in Russian Karelia by the year 2003 (5).